Biorealism's neighborhood:

Slurs & ToS Breaches Nazi Dogwhistles Antisemitism Transphobia Anti-Blackness Homophobia Misogyny Groypers Proud Boys Patriot Front
Matched Tweets Image Guesses - 315
Holtz @Biorealism
@BenFPiercePhD They could have added evidence for lineage A in the market is based on N=1 glove out of 1380 environmental & animal samples tested on 1 January 2020. Also, apparently not an early case based on other mutations in that sample. https://link.medium.com/8x2fKu3vdAb

Copy as image

Copied to clipboard!

Holtz @Biorealism
@BenFPiercePhD Out of frame isn't a particularly strong argument? It never arose during the Proximal Origin discussions and seems unconvincing. @jbkinney @BiophysicsFL

Copy as image

Copied to clipboard!

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Ayjchan @chasewnelson Also, there are potentially much earlier cases that weren't picked up in the retrospective search. Peter Ben Embarek suggested there were likely thousands of cases in Wuhan in December 2019. Earlier sequences too per work by Kumar et al and Jesse Bloom.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Muller_Lab @BenFPiercePhD @Ayjchan Yes, @LauraKahn1 has covered some of the differences. https://gjia.georgetown.edu/2023/03/03/the-seven-deadly-sins-of-biomedical-research/

Copy as image

Copied to clipboard!

Holtz @Biorealism
@greedwashing @doritmi @WalkerBragman @TheAtlantic @KatherineJWu @TheVertlartnic @DougJBalloon @nxthompson @CaulfieldTim @_everythingism You realize that market origin and lab origin both rest on conspiracies to conceal evidence? In the case of WIV the NIH terminated their subaward last year for continued refusal to share records of their SrCVs research.

Copy as image

Copied to clipboard!

Copy as image

Copied to clipboard!

Holtz @Biorealism
@erasmuse @KirkegaardEmil Yes, something @charlesmurray suggested in an NY Times interview about Real Education. https://www.nytimes.com/2008/09/21/magazine/21wwln-Q4-t.html

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Bryce_Nickels @flowermusickids @R_H_Ebright @thackerpd Philipp Markolin PhD is wrong and an asshole.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@AntGDuarte @stuartjdneil @Ticklicker56 It's interesting to see Christian Drosten's comments in this March 2020 interview about dubious speculation about the origin of SARS-CoV-2. He seemed to find the pangolin data unconvincing (English translation). https://www.ndr.de/nachrichten/info/6-Coronavirus-Update-Aerzte-und-Pfleger-regelmaessig-testen,podcastcoronavirus120.html

Copy as image

Copied to clipboard!

Holtz @Biorealism
Christian Drosten, later revealed to be on the Fauci call, in March 2020: There are scientists who are interested in quick, fluffy, superficial papers and quick investigations that can be published in the highest-ranking scientific journals possible. https://t.co/WMp9vFGtP4 https://t.co/ePknPkyGho
Holtz @Biorealism
: we have to take a look at the academic evaluation system... how research and research incentives do not become misleading. And to put it very briefly again, the one with the pangolin is a duck. Data was published that explains anything but the origin of this virus.

Copy as image

Copied to clipboard!

Holtz @Biorealism
Christian Drosten, later revealed to be on the Fauci call, in March 2020: There are scientists who are interested in quick, fluffy, superficial papers and quick investigations that can be published in the highest-ranking scientific journals possible. https://www.ndr.de/nachrichten/info/6-Coronavirus-Update-Aerzte-und-Pfleger-regelmaessig-testen,podcastcoronavirus120.html

Copy as image

Copied to clipboard!

Holtz @Biorealism
@DamianHron @born_orwellian @robinhanson Or how many species are there? It's unanswerable. Something Jerry Coyne noted in terms of races. https://whyevolutionistrue.com/2012/02/28/are-there-human-races/

Copy as image

Copied to clipboard!

Holtz @Biorealism
@SSbike @adrianweckler Yes, my point is that things are often less black and white than that particularly on scientific issues. We've seen that with Covid where it wasn't airborne, then masks don't work, then they do etc. Scientists often disagree. Community Notes has been a useful feature IMO.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@SSbike @adrianweckler Yes, my point is that things are often less black and white than that particularly on scientific issues. We've seen that with Covid where it wasn't airborne, then masks don't work, then they do etc. Scientists often disagree. Community Notes has been a useful feature IMO.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@RicketRobin @JonPloug Is there even evidence Pangolins were sold at Huanan seafood market? This study in which vendors did admit to selling various species illegally found no pangolins were sold. https://www.nature.com/articles/s41598-021-91470-2

Copy as image

Copied to clipboard!

Holtz @Biorealism
@jordixiol @Ayjchan None in the wild so far. @Ticklicker56 has discussed the Freuling et al study.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@KitGregson @ThierryBreton That's a core component of democracy and open society. Twitter doesn't actually allow free speech in any case. If you look up the reporting features there are many prohibitions on what people can tweet that already address these concerns.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @BenFPiercePhD The wider context is journalists & physicians being reprimanded or imprisoned for reporting on the outbreak in the first place. WHO mission leader Peter Ben Embarek said they were unable to mention lab origin unless it was on the basis there would be no specific studies.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@BenFPiercePhD "We thank Yujia Alina Chan and Shing Hei Zhan for bringing the errors to our attention".

Copy as image

Copied to clipboard!

Holtz @Biorealism
@BenFPiercePhD The point Nikolai Petrovsky and David Winkler noted was humans topped the list for binding affinity. That was unexpected. They discuss that in their paper and the lack of further selection early on. Not sure if Viral mentions their work? https://www.nature.com/articles/s41598-021-92388-5

Copy as image

Copied to clipboard!

Holtz @Biorealism
@a_solveig96 @Ayjchan "We thank Yujia Alina Chan and Shing Hei Zhan for bringing the errors to our attention."

Copy as image

Copied to clipboard!

Holtz @Biorealism
@quay_dr Technology improved living conditions but allowed people to separate intercourse from reproduction. A significant factor in the decline in birth rates.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@mbalter When I posted this I mistakenly thought it was from 2023! The latest comment I can see from Gupta on this is in an interview in October 2021 where he discusses DEFUSE. https://t.co/tJvPdQXcAx https://t.co/qdJImIJZcu
Holtz @Biorealism
: @mbalter Gupta apparently also discussed lab origin in his book World War C that came out in October 2021. https://blog.piaw.net/2021/12/review-world-war-c.html?m=1

Copy as image

Copied to clipboard!

Holtz @Biorealism
@mbalter When I posted this I mistakenly thought it was from 2023! The latest comment I can see from Gupta on this is in an interview in October 2021 where he discusses DEFUSE. https://www.mediaite.com/podcasts/sanjay-gupta-on-wuhan-lab-leak-theory-where-there-is-smoke-theres-fire-but-we-may-never-know-the-truth/

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @cobrownell @chasewnelson @AntGDuarte From Steven Quay's report, Wuhan Institute of Virology was serviced by Line 2 which runs through Hankou Station a 15 minute walk to Huanan Seafood market. There's also the issue of ascertainment bias with how early cases were recorded unfortunately. https://zenodo.org/record/4119263

Copy as image

Copied to clipboard!

Holtz @Biorealism
@BCNThomson @Ayjchan "We thank Yujia Alina Chan and Shing Hei Zhan for bringing the errors to our attention."

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @TheRichFromCali @hitorque @R_H_Ebright Carl T Bergstrom was explicit that lifting the decision of the NIH which Fauci and Collins supported risked millions of lives.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@TheRichFromCali @hitorque In 2017, the moratorium on gain-of-function research on potential pandemic pathogens like SARS was reviewed in secret, then quietly lifted by the NIH, in part because Drs. Fauci and Frances Collins, head of the NIH, did not want the funding to end. https://www.tabletmag.com/sections/science/articles/plague-on-both-our-houses

Copy as image

Copied to clipboard!

Holtz @Biorealism
@PetalumaPegleg @hankgreen @JDVance1 It's *one* component of demand so an obvious policy lever to consider (the govt doesn't target 50 mill annually either). Not sure why this should be any more contentious than suggesting land use regulations are one policy component in terms of supply.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@KevinaFaga @espiers Grip strength differences are fairly stark.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @lableakdude @neuropunkd @kerpen @DrJBhattacharya The features of the virus, including the furin site never seen before in sarbecoviruses, humans topping the list for binding affinity from the outset, the restriction sites, are all explained by lab origin.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@EckerleIsabella @whittakerIDlab Bernd Kaina previously noted some similarities between these including the proline in the FCS. Interesting paper. https://iv.iiarjournals.org/content/35/3/1313/tab-figures-data

Copy as image

Copied to clipboard!

Holtz @Biorealism
In the egalitarian context of Norway, additive genetics overall account for around 40% of the variation in class outcomes among twins, while shared environments account for around 10% of this variation and roughly 50% by unshared environments. https://osf.io/preprints/socarxiv/mncet/

Copy as image

Copied to clipboard!

Holtz @Biorealism
@scotub @desktopcarl @DavidBahry @abhishek_s_1 @MarionKoopmans @PeterDaszak Amongst other responses to Pekar et al. no proper discounting of all the intermediates, several papers have found a progenitor to the A-B split, evidence for lineage A in the market is based on N=1 glove out of 1380 environmental & animal samples tested on 1 January 2020.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @SamLeeming @NieceOfFester @SteveO25290456 @BrentLeeSDCIC @scotub recommend any studies to consider that hypothesis and they haven't seen their database. Hence WHO is still asking for this information to be shared and the NIH terminated their subaward to the Wuhan Institute of Virology last year for refusal to share their SrCVs.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @SamLeeming @NieceOfFester @SteveO25290456 @BrentLeeSDCIC The market theory, which I take it Markolin favors, rests on what David Relman described as "hopelessly impoverished" early case data. WHO hasn't accepted market origin in particular as there are much earlier cases than those linked to the market in December 2019. Eg. @scotub

Copy as image

Copied to clipboard!

Holtz @Biorealism
@BiophysicsFL @MJnanostretch @berkley_lynch @OYCar Indeed. @EmaNymton90 notes you would expect some changes just from drift alone.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@sensiN23 @Eyeoftg @davidpgoldman Well it needs to be explained how it emerged in Wuhan. Let alone with a furin site with no surrounding amino acid changes in comparison to Banal-52. Lab origin explains this given WIV's sampling history and research proposals.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @Eyeoftg @sensiN23 @davidpgoldman Per @BiophysicsFL DEFUS3 explains several features: 🟡Mice with humanized ACE2 [adaptation to humans] 🟢Making novel infectious clones 🟠"Unknown recombinants" [Backbone doesn't match known systems] 🟣Inserting a furin cleavage site [Only SarbeCoV with an FCS]

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Eyeoftg @sensiN23 @davidpgoldman @R_H_Ebright Thanks, although when Jesse Bloom analysed the data it turned out there was a *negative* correlation between abundance of SARS-COV-2 and mitochondrial genetic material from raccoon dogs and that stall was negative by RT-qPCR, but had 1 of 200,000,000 reads mapping to SARS2.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Eyeoftg @sensiN23 @davidpgoldman Baltimore did clarify his "smoking gun" statement but the claim the FCS is known to be natural is unsupported. It's unknown. It's one of several features of SC2, that are puzzling. Another being the binding affinity to human ACE2 which Nikolai Petrovsky and David Winkler noted.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Eyeoftg @sensiN23 @davidpgoldman @R_H_Ebright Yes, it's not a sarbecovirus. While Wuhan Institute of Virology was part of a proposal to add furin cleavage sites into novel SARS-related bat coronaviruses. So the location of the outbreak in Wuhan rather than near any of the ~40,000 wet markets in China is suggestive.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Eyeoftg @sensiN23 @davidpgoldman No closer relatives have been found despite extensive sampling around Wuhan since. It's not clear either way whether the FCS arose naturally or not, but it's always been a puzzle as Baltimore notes in the Wade piece. The market seems unlikely given earlier sequences and cases.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @Eyeoftg @sensiN23 @davidpgoldman @R_H_Ebright Carl T. Bergstrom explicitly warned in December 2017 that lifting the moratorium could start a pandemic that would kill millions. This scenario was entirely foreseeable.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@KorlicTheGreat @NRO @yangjianli001 Lab origin always likely. Nearest SC2 relatives are found in Yunnan & Laos. Both areas the Wuhan Institute of Virology was sampling. They refuse to share their records. Now known to be part of a proposal to add furin cleavage sites into novel SARS-related bat coronaviruses.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@mbalter @walizonia @mattklewis And as Richard A. Muller found with his virology colleagues, there are strong incentives *against* discussing the lab origin scenario. https://t.co/FrkMOM3N8W
Holtz @Biorealism
: @mbalter @walizonia @mattklewis Another reason why it's interesting to see the private views of various experts on the subject given it's controversial to publicly suggest lab origin is likely in this field.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @mbalter @walizonia @mattklewis And as Richard A. Muller found with his virology colleagues, there are strong incentives *against* discussing the lab origin scenario.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@JamesDebord18 @walizonia @mattklewis @DavidBahry Yes, he was. Here is his comment. https://portside.org/2021-09-05/call-wild

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @JamesDebord18 @walizonia @mattklewis @DavidBahry Jesse Bloom has also highlighted that there are earlier sequences and cases which hold the answer to the origins of SARS-CoV-2. The evidence at the moment does not establish market origin or exclude lab origin as was suggested above.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@rodthelimey @angoffinet @GurusPod @BillyBostickson @Ayjchan @mattwridley Chris Kavanagh in a nutshell.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@AshurTheCreator @agingdoc1 Abram Hoffer 1989: "Jacobson and Jacobson [Hostetler (1978)] believe niacin (more specifically NAD) prevents processes which lead to cancer." https://isom.ca/article/niacin-coronary-disease-longevity/

Copy as image

Copied to clipboard!

Holtz @Biorealism
@breakfast_dogs @SteveBigpond @R_H_Ebright @Florin_Uncovers @ColinDavdButler @BallouxFrancois @FatEmperor @ronandsarah @RJEdwardsTweets @CharlesRixey @lab_leak @InWuchang @WashburneAlex @capitolsheila @MonaRahalkar @stevenemassey "The team found that the number of fake papers had risen substantially in recent years. Pressure to publish had been particularly intense in China, they said; for example, some Chinese hospitals and health authorities require physicians to be first author on a set number of…

Copy as image

Copied to clipboard!

Holtz @Biorealism
The team found that the number of fake papers had risen substantially in recent years. https://www.ft.com/content/76abf920-effb-4d66-8fb2-3ff842150297

Copy as image

Copied to clipboard!

Copy as image

Copied to clipboard!

Holtz @Biorealism
@hholdenthorp Good comments, just unfortunate you haven't exactly demonstrated this commitment to the scientific process with your advocacy on SARS-COV-2 origins and refusal to consider papers that contradict your stance.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@maelouisewoods @Bryce_Nickels I agree with Thorp's comments here, it's just unfortunate he hasn't exactly demonstrated this commitment to the scientific process with his advocacy on SARS-COV-2 origins and refusal to consider papers that contradict his stance.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@BiophysicsFL Bob Garry treated the double spillover theory as fact. https://www.pnas.org/doi/10.1073/pnas.2211107119

Copy as image

Copied to clipboard!

Holtz @Biorealism
@___Ksquared___ Book

Copy as image

Copied to clipboard!

Holtz @Biorealism
Alex Kroll: I got into the habit of setting goals which were uncomfortable (I've always been very confident that I'm very lazy at heart, and in order to suck me out of my lethargy, in order for me to allow that natural compulsion to be a slug, I had to set uncomfortable goals).

Copy as image

Copied to clipboard!

Holtz @Biorealism
David Mahoney: When I was young I thought that people at the top really understood what the hell was happening...whether they were cardinals or bishops or generals or politicians or business leaders. They knew. Well, I'm up there, and now I know they don't know. https://t.co/3JbhFHqwjT
Holtz @Biorealism
: Nolan Bushnell: I consistently believed that there are experts and there aren't. Whenever I've wanted to surrender good judgment to a Santa Claus, I get disappointed.

Copy as image

Copied to clipboard!

Holtz @Biorealism
David Mahoney: When I was young I thought that people at the top really understood what the hell was happening...whether they were cardinals or bishops or generals or politicians or business leaders. They knew. Well, I'm up there, and now I know they don't know.

Copy as image

Copied to clipboard!

Holtz @Biorealism
de Bono 1985: reached such a point of complexity it may not be within the power of the individual to make the right decisions. Perhaps we shall be in this state until our 'fifth generation' computers can take over this thinking job for us. That may herald even greater dangers.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@RavenOnthill @dwallacewells @mike_cal Nearest relatives to SARS-CoV-2 are found in Yunnan and Laos. Both areas the Wuhan Institute of Virology was sampling. They were part of a proposal to add furin cleavage sites into novel SARS-related bat coronaviruses as Nick Patterson notes. They refuse to share their records.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@gregatval @Ayjchan The wildest rationalization I've seen so far

Copy as image

Copied to clipboard!

Holtz @Biorealism
@MonaRahalkar @angoffinet With some restrictions to quietly acknowledge some of the things EcoHealth Alliance did were too risky (potentially caused the pandemic).

Copy as image

Copied to clipboard!

Holtz @Biorealism
@JGosham @SenKatyG @Greens @DavidPocock Jared Diamond pointed out the Big Australia policy was environmentally unsustainable in Collapse. You would think the Greens would be concerned about that aside from obviously being irresponsible in a housing crisis. #auspol

Copy as image

Copied to clipboard!

Holtz @Biorealism
@SenKatyG @Greens @DavidPocock Surely if Greens and others were concerned about Australia's crisis housing they would have listened to Jared Diamond who pointed out the fallacy of a Big Australia policy. Aside from being environmentally unsustainable it drives demand for housing and rentals.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@willingl @JamieMetzl When there is a disaster that leads to mass casualties there is a duty to understand how it happened and to prevent a recurrence. In this case there were specific warnings against lifting the moratorium on gain-of-function research on potential pandemic pathogens like SARS.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@alchemytoday @JamieMetzl ??

Copy as image

Copied to clipboard!

Holtz @Biorealism
@rebelfd @R_H_Ebright @JamieMetzl He is mistaken. Marion Koopmans made the same mistake (she later acknowledged she was incorrect).

Copy as image

Copied to clipboard!

Holtz @Biorealism
@RicketRobin @ydeigin Yes, Marion Koopmans was corrected and eventually acknowledged she was incorrect although didn't delete her misleading initial tweet.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@jtmayes3 @ydeigin @BiophysicsFL Apart from SARS-COV-2 none has been found to date? Note that in comparison to Banal-52 SARS-COV-2 has the 12nt insertion that adds the furin site with no surrounding amino acid changes.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@jtmayes3 @ydeigin It's not going to recombine with a sarbecovirus. See also comments by @BiophysicsFL

Copy as image

Copied to clipboard!

Holtz @Biorealism
@jh336405 @R_H_Ebright SARS-COV-2 was well adapted to human ACE2 cells from the outset. In 2019 Daszak was touting they had hACE2 binding and humanized mouse infection with synthetic recombinant bat coronaviruses. WIV have refused to share their records with the NIH.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @TRyanGregory @R_H_Ebright The new restrictions under the award seem like a concession this work could have lead to SARS-CoV-2 or to a future outbreak.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@NIHDirector @publicservice @aphillippy @sergekoren @ArangRhie @theNCI EcoHealth Alliance NYC shared a "Viruses and Genetic Resource Database" with Wuhan Institute of Virology. Has this been shared with the NIH? @COVIDSelect http://web.archive.org/web/20201102074943/http://institute.wuhanvirology.org/International_Cooperation2016/International_Projects2016/

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Bryce_Nickels @LarryBoorstein EcoHealth Alliance had a shared database with Wuhan Institute of Virology. Any chance that could be obtained @COVIDSelect? http://web.archive.org/web/20201102074943/http://institute.wuhanvirology.org/International_Cooperation2016/International_Projects2016/

Copy as image

Copied to clipboard!

Holtz @Biorealism
@R_H_Ebright @JamieMetzl Indeed. https://t.co/O7dEdP7f0x
Holtz @Biorealism
: @R_H_Ebright @JamieMetzl Meanwhile, the nearest relatives to SARS-CoV-2 are found in Yunnan and Laos. Areas the Wuhan Institute of Virology sampled. Compared to Banal-52, SARS-CoV-2 has a furin cleavage site with no surrounding amino acid changes.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@R_H_Ebright @JamieMetzl Indeed. https://t.co/O7dEdP7f0x
Holtz @Biorealism
: @R_H_Ebright @JamieMetzl Meanwhile, the nearest relatives to SARS-CoV-2 are found in Yunnan and Laos. Areas the Wuhan Institute of Virology sampled. Compared to Banal-52, SARS-CoV-2 has a furin cleavage site with no surrounding amino acid changes.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@R_H_Ebright @JamieMetzl Indeed. https://t.co/O7dEdP7f0x
Holtz @Biorealism
: @R_H_Ebright @JamieMetzl Meanwhile, the nearest relatives to SARS-CoV-2 are found in Yunnan and Laos. Areas the Wuhan Institute of Virology sampled. Compared to Banal-52, SARS-CoV-2 has a furin cleavage site with no surrounding amino acid changes.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@R_H_Ebright @JamieMetzl Indeed.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@R_H_Ebright @JamieMetzl Indeed.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @fitterhappierAJ @JamieMetzl @BiophysicsFL Meanwhile, the nearest relatives to SARS-CoV-2 are found in Yunnan and Laos. Areas the Wuhan Institute of Virology sampled. Compared to Banal-52 SARS-CoV-2 has a furin cleavage site with no surrounding amino acid changes.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@harishseshadri2 @dasher8090 @HL3133 Daszak is presumably protected?

Copy as image

Copied to clipboard!

Holtz @Biorealism
@MartinWBastard @R_H_Ebright @AGHuff Andrew Rambaut didn't think so. In any case, Peter Daszak's behavior since the pandemic started has brought the organization into disrepute unfortunately.

Copy as image

Copied to clipboard!

Holtz @Biorealism
How journals can close ranks. Bill Hamilton, one of the leading evolutionary biologists of the 20th century, wrote to Science & Nature on the theory AIDS originated from live polio vaccines prepared in chimpanzee tissue cultures. Rejected by both, perhaps using the same reviewer.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@RFfromMass @BostonGlobe @GlobeIdeas Humans topped the list for binding affinity from the outset. The furin site isn't seen in other sarbecoviruses. It's since come to light WIV was part of a proposal to add furin cleavage sites into novel SARS-related bat coronaviruses. https://t.co/qTpJMaR0Am https://t.co/1IYkXPu5eW
Holtz @Biorealism
: @RFfromMass @BostonGlobe @GlobeIdeas Nikolai Petrovsky and David Winkler, two of the authors of the Nature paper above, note how unexpected this finding was. WIV had hACE2 binding and humanized mouse infection with synthetic recombinant bat coronaviruses in 2019 too.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@RFfromMass @BostonGlobe @GlobeIdeas Humans topped the list for binding affinity from the outset. The furin site isn't seen in other sarbecoviruses. It's since come to light WIV was part of a proposal to add furin cleavage sites into novel SARS-related bat coronaviruses. https://www.nature.com/articles/s41598-021-92388-5

Copy as image

Copied to clipboard!

Holtz @Biorealism
@EnricoAndDionne @dancalegria @MarionKoopmans Great interview with Sachs who chaired the Lancet Covid19 Commission and was stunned by the obfuscation and misdirection. https://www.currentaffairs.org/2022/08/why-the-chair-of-the-lancets-covid-19-commission-thinks-the-us-government-is-preventing-a-real-investigation-into-the-pandemic

Copy as image

Copied to clipboard!

Holtz @Biorealism
@IttyBittyGrem @TheFamousArtBR @SydneyLWatson That men tend to have physical advantages for most sports. Eg. https://pubmed.ncbi.nlm.nih.gov/35897465/

Copy as image

Copied to clipboard!

Holtz @Biorealism
@M_Raviglione @user3425664 Even WHO thinks it started before December. Hence they haven't accepted market origin.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@lab_leak @WashburneAlex @babarlelephant @Stephengm99 @stevenemassey @Rebecca21951651 @mbalter @guardian @nytimes @TheAtlantic @BBC @NPR @scotub No, they didn't venture an estimate for that. Just the when the progenitor evolved. https://academic.oup.com/bioinformatics/article/38/10/2719/6553661

Copy as image

Copied to clipboard!

Holtz @Biorealism
@battleforeurope Fauci lying again just as he did before Congress when he denied funding gain-of-function research in Wuhan.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@salmarchaudhry @NewsNation Computational biologist Nick Patterson: the leak of the DARPA grant proposal changed my view. I now think that by far the most likely cause of the pandemic was an accidental leak of an engineered virus.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @JonPloug @gdemaneuf @michaelzlin More history - EHA-WIV-UNC-NUS proposal: 🟡Mice with humanized ACE2 [adaptation to humans] 🟢Making novel infectious clones 🟠"Unknown recombinants" [Backbone doesn't match known systems] 🟣Inserting a furin cleavage site [Only SarbeCoV with an FCS]

Copy as image

Copied to clipboard!

Holtz @Biorealism
@WashburneAlex @babarlelephant @Stephengm99 @stevenemassey @lab_leak @Rebecca21951651 @mbalter @guardian @nytimes @TheAtlantic @BBC @NPR See also, analysis based on excess mortality data per @scotub, who now estimates around 3,000 cases by Dec. 1. Mai He & Lucia Dunn's analysis implied the outbreak began in October or late September 2019 (consistent with Kumar et. al. 2022). https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3540636

Copy as image

Copied to clipboard!

Holtz @Biorealism
@BBCWorld Computational biologist Nick Patterson: the leak of the DARPA grant proposal changed my view. I now think that by far the most likely cause of the pandemic was an accidental leak of an engineered virus.

Copy as image

Copied to clipboard!

Holtz @Biorealism
The overall conclusion is that this work strongly supports the hypothesis of the probable human origin of the SARS-CoV-2 polybasic PRRA furin cleavage site. https://scholar.google.com/scholar?as_ylo=2023&hl=en&as_sdt=2005&sciodt=0,5&cites=12391157489224931254&scipsc=#d=gs_qabs&t=1680853442786&u=%23p%3DLqnrtAqJkWAJ

Copy as image

Copied to clipboard!

Holtz @Biorealism
@DC_Draino Legendary computational biologist Nick Patterson: the leak of the DARPA grant proposal changed my view. I now think that by far the most likely cause of the pandemic was an accidental leak of an engineered virus.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Rebecca21951651 @arstechnica @BethMarieMole There remains no evidence of infected animals. More fundamentally WHO don't accept market origin as there were earlier cases.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@BillHanage Whatever the case, WHO aren't persuaded by the early case data that David Relman described as "hopelessly impoverished". There are earlier cases so all hypotheses remain on the table. https://t.co/EKBxAtJMgH
Holtz @Biorealism
: @BillHanage Maria Van Kerkhove on the need for the PRC to share data on the animal trade and the operation of labs working on coronaviruses, the earliest potential cases and lab audit data. https://www.science.org/doi/10.1126/science.adi0490

Copy as image

Copied to clipboard!

Holtz @Biorealism
@BillHanage Whatever the case, WHO aren't persuaded by the early case data that David Relman described as "hopelessly impoverished". There are earlier cases so all hypotheses remain on the table.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@scotub @BillHanage Should address WIV sampling Yunnan & Laos + DEFUSE @BiophysicsFL 🟡Mice with humanized ACE2 [adaptation to humans] 🟢Making novel infectious clones 🟠"Unknown recombinants" [Backbone doesn't match known systems] 🟣Inserting a furin cleavage site [Only SarbeCoV with an FCS] https://t.co/5Scv2kw6zP
Holtz @Biorealism
: @scotub @BillHanage @BiophysicsFL Aside from the work the NIAID funded, CAS funded a proposal at the Wuhan Institute of Virology to use infectious cloning to make recombinant SARS coronaviruses. The results of this are unknown.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@scotub @BillHanage Should address WIV sampling Yunnan & Laos + DEFUSE @BiophysicsFL 🟡Mice with humanized ACE2 [adaptation to humans] 🟢Making novel infectious clones 🟠"Unknown recombinants" [Backbone doesn't match known systems] 🟣Inserting a furin cleavage site [Only SarbeCoV with an FCS]

Copy as image

Copied to clipboard!

Holtz @Biorealism
@kellywind @RadCentrism @tgof137 @MichaelWorobey @edwardcholmes Yes, aside from the work the NIAID funded, the CAS funded a proposal at the Wuhan Institute of Virology to use infectious cloning to make recombinant SARS coronaviruses. The results of this are unknown.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@RadCentrism @kellywind @tgof137 @MichaelWorobey @edwardcholmes I suspect WIV overall given sampling Yunnan & Laos, part of DEFUSE: 🟡Mice with humanized ACE2 [adaptation to humans] 🟢Making novel infectious clones 🟠"Unknown recombinants" [Backbone doesn't match known systems] 🟣Inserting a furin cleavage site [Only SarbeCoV with an FCS]

Copy as image

Copied to clipboard!

Holtz @Biorealism
@mbalter @scotub @laurahelmuth @sipappas @sciam @sarahkendzior And then what happens when the claimed 'consensus' position is acknowledged to be a conspiracy? 🤯

Copy as image

Copied to clipboard!

Holtz @Biorealism
@scotub @tgof137 @kellywind @MichaelWorobey @edwardcholmes Peter Ben Embarek who lead the WHO team to Wuhan later said there were likely already thousands of cases in December 2019.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@tgof137 @kellywind @MichaelWorobey @edwardcholmes @scotub Part of flu season. School postponements in early November 2019. Doctors alerted to a particularly severe influenza. Unfortunately athletes who reported symptoms consistent with SC2 from the Military Games in October appear not to have had serology tests.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@tgof137 @kellywind @MichaelWorobey @edwardcholmes Earlier cases are the reason WHO and the Taiwanese CECC haven't accepted market origin. The excess mortality data suggests this. https://t.co/WuBdmlpDLq
Holtz @Biorealism
: @tgof137 @kellywind @MichaelWorobey @edwardcholmes If anything that is a conservative estimate. See for example @scotub, or Lucia Dunn & Mai He who estimated "[t]he coronavirus outbreak began in October or late September 2019." https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3540636

Copy as image

Copied to clipboard!

Holtz @Biorealism
@tgof137 @kellywind @MichaelWorobey @edwardcholmes Earlier cases are the reason WHO and the Taiwanese CECC haven't accepted market origin. The excess mortality data suggests this.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@flor8i @edwardcholmes @ClaWuest Even looking at the environmental samples taken in January 2020 that the raccoon dog report relies on, the most elevated risk is centred on the toilets and Mahjong room upstairs. This is omitted by Holmes & co. @BiophysicsFL @stevenemassey @humblesci https://t.co/28Fv8qRn1r https://t.co/EGX6lcF8MZ
Holtz @Biorealism
: @flor8i @edwardcholmes @ClaWuest @BiophysicsFL @stevenemassey @humblesci Notably, no wildlife vendors were amongst the recorded cases which contrasts markedly with SARS1.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@flor8i @edwardcholmes @ClaWuest WHO and the Taiwanese CECC figured out Sars-CoV-2 didn't come from the market a while ago. The earliest cases predate the market cases. https://t.co/6G80N0l9Lx
Holtz @Biorealism
: @flor8i @edwardcholmes @ClaWuest Even looking at the environmental samples taken in January 2020 that the raccoon dog report relies on, the most elevated risk is centred on the toilets and Mahjong room upstairs. This is omitted by Holmes & co. @BiophysicsFL @stevenemassey @humblesci https://zenodo.org/record/7212687

Copy as image

Copied to clipboard!

Holtz @Biorealism
@WashburneAlex Reminder that, the year before the pandemic, Holmes collaborated with the Wuhan Institute of Virology to study novel SARS-like viruses they sampled in China but didn't declare this in Proximal Origin.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @HansMahncke @flor8i @edwardcholmes @ClaWuest The year before the pandemic, Eddie Holmes collaborated with the Wuhan Institute of Virology to study novel SARS-like viruses they sampled in China. This was not declared as a conflict of interest in Proximal Origin.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@egli_pascal @flor8i @edwardcholmes @ClaWuest Holmes has been making overconfident claims dismissing lab origin for 3 years. More sober assessments are made by the likes of David Relman, Jesse Bloom, Francois Balloux.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@GesundheitsPER @flor8i Holmes went from privately saying it was 80% likely it came from the lab to publicly saying it definitely did not based on what turned out to be contaminated pangolin data. Now he's moved onto raccoon dogs even though there were cases that predate the market ones. https://t.co/vMS17c9ztt
Holtz @Biorealism
: @GesundheitsPER @flor8i Hence WHO and the Taiwanese CECC, US Dept of Energy Z-Division, FBI, Jesse Bloom, David Fisman, David Relman don't find market origin convincing.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@GesundheitsPER @flor8i Holmes went from privately saying it was 80% likely it came from the lab to publicly saying it definitely did not based on what turned out to be contaminated pangolin data. Now he's moved onto raccoon dogs even though there were cases that predate the market ones.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@flor8i @edwardcholmes @ClaWuest WHO and the Taiwanese CECC figured out Sars-CoV-2 didn't come from the market a while ago. The earliest cases predate the market cases.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@breakfast_dogs @angoffinet The question is will Stuart Neil call out the organizers for having a speaker who has actively witheld data relevant to the origins of SARS-CoV-2 from the international community and WHO? #NIDO2023

Copy as image

Copied to clipboard!

Holtz @Biorealism
@michaelzlin @john_bumblebee WHO figured out the pandemic probably didn't start at the market a while ago. https://t.co/lhRhOE8AAg https://t.co/XpDdWKKwhM
Holtz @Biorealism
: @michaelzlin @john_bumblebee It's interesting WHO used excess mortality data to determine earlier cases. @scotub has done the same below. Lucia Dunn & Mai He estimated "[t]he coronavirus outbreak began in October or late September 2019." https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3540636

Copy as image

Copied to clipboard!

Holtz @Biorealism
@michaelzlin @john_bumblebee WHO figured out the pandemic probably didn't start at the market a while ago. https://usrtk.org/biohazards/senior-who-official-expressed-doubts-that-covid-19-began-in-wet-market/

Copy as image

Copied to clipboard!

Holtz @Biorealism
@LubbersTonnie @john_bumblebee @MarionKoopmans @franciscodeasis @TheSeeker268 @BillyBostickson Peter Daszak can afford to be arrogant.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@FatEmperor @SteveBigpond @breakfast_dogs @R_H_Ebright @Florin_Uncovers @ColinDavdButler @taipan168 @MCCCANM @Rebecca21951651 @emilyakopp @MonaRahalkar @capitolsheila @ronandsarah @EthicalSkeptic Peter Ben Embarek who lead the WHO mission to Wuhan has also said that in December 2019 there were "likely already thousands of cases in Wuhan." https://t.co/MhT0Foc8qC
Holtz @Biorealism
: @FatEmperor @SteveBigpond @breakfast_dogs @R_H_Ebright @Florin_Uncovers @ColinDavdButler @taipan168 @MCCCANM @Rebecca21951651 @emilyakopp @MonaRahalkar @capitolsheila @ronandsarah @EthicalSkeptic It's interesting WHO used excess mortality data to determine earlier cases. @scotub has done the same below. Lucia Dunn & Mai He estimated "[t]he coronavirus outbreak began in October or late September 2019." https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3540636

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @FatEmperor @SteveBigpond @breakfast_dogs @R_H_Ebright @Florin_Uncovers @ColinDavdButler @taipan168 @MCCCANM @Rebecca21951651 @emilyakopp @MonaRahalkar @capitolsheila @ronandsarah @EthicalSkeptic Peter Ben Embarek who lead the WHO mission to Wuhan has also said that in December 2019 there were "likely already thousands of cases in Wuhan."

Copy as image

Copied to clipboard!

Holtz @Biorealism
@northernsoulboy @Telegraph What? WHO have known for sometime Covid didn't originate at the market.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@SteveBigpond @breakfast_dogs @R_H_Ebright @Florin_Uncovers @ColinDavdButler @taipan168 @MCCCANM @Rebecca21951651 @emilyakopp @MonaRahalkar @capitolsheila @ronandsarah @FatEmperor @EthicalSkeptic Something WHO figured out a while ago.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@liviadrusilla90 @stuartjdneil @GISAID Indeed. WHO don't accept Stuart's nonsense about the market either.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@oiwoods @NMowbray23 @KiwibankNZ @nzherald @shaneellall Jacquie Grant is 'punching down' too? https://www.chrislynchmedia.com/news-items/mej9csdt2gpatwhxa22ojobj0pgshw

Copy as image

Copied to clipboard!

Holtz @Biorealism
@CD57227 @BenthemJoost Dr Tedros saw through the obvious sham and @MarionKoopmans was annoyed?

Copy as image

Copied to clipboard!

Holtz @Biorealism
@JonPloug @MJnanostretch That applies even more so for lab origin. In any case, WHO doesn't accept market origin as there were earlier cases.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@KanekoaTheGreat @elonmusk Computational biologist Nick Patterson: the leak of the DARPA grant proposal changed my view. I now think that by far the most likely cause of the pandemic was an accidental leak of an engineered virus.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@michaelpsenger Computational biologist Nick Patterson: the leak of the DARPA grant proposal changed my view. I now think that by far the most likely cause of the pandemic was an accidental leak of an engineered virus.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@hsu_steve One example of how his campaigns used big data to target potential voters. https://www.technologyreview.com/2012/12/19/114510/how-obamas-team-used-big-data-to-rally-voters/

Copy as image

Copied to clipboard!

Holtz @Biorealism
@ZaffranRiver @RaveCozensHardy The Obama campaigns did too? This is one example from the article. https://www.technologyreview.com/2012/12/19/114510/how-obamas-team-used-big-data-to-rally-voters/

Copy as image

Copied to clipboard!

Holtz @Biorealism
@DouthatNYT @lpolgreen @CarlosNYT @mcottle Any idea why Times' reporting on Covid origins has become so misleading? This is the response from veteran science journalist Michael Balter. https://t.co/RMXpXyh6Ys
Holtz @Biorealism
: @DouthatNYT @lpolgreen @CarlosNYT @mcottle Stanford's Michael Lin.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@DouthatNYT @lpolgreen @CarlosNYT @mcottle Any idea why Times' reporting on Covid origins has become so misleading? This is the response from veteran science journalist Michael Balter.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@bill_kipper @TRyanGregory They haven't discussed DEFUSE WIV was part of? @BiophysicsFL 🟡Mice with humanized ACE2 [adaptation to humans] 🟢Making novel infectious clones 🟠"Unknown recombinants" [Backbone doesn't match known systems] 🟣Inserting a furin cleavage site [Only SarbeCoV with an FCS]

Copy as image

Copied to clipboard!

Holtz @Biorealism
@TRyanGregory Computational biologist Nick Patterson: the leak of the DARPA grant proposal changed my view. I now think that by far the most likely cause of the pandemic was an accidental leak of an engineered virus.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@TWenseleers Highest statistically significant elevation in density of positive environmental samples relative to samples stall distribution is centered on the Huanan seafood market toilets. @gdemaneuf @humblesci https://zenodo.org/record/7212687#.ZBu_jaTRVkw

Copy as image

Copied to clipboard!

Holtz @Biorealism
@EmaNymton90 @gjvdkamp @TWenseleers @jbloom_lab See also @DavidBahry https://t.co/F83Bci6yKZ https://t.co/xqqa39jTWc
Holtz @Biorealism
: @EmaNymton90 @gjvdkamp @TWenseleers @jbloom_lab @DavidBahry Also, aside from a sampling being skewes towards the SW corner, they omit the toilets which were where the highest statistically significant elevation of positive environmental samples relative to samples stall distribution is found @humblesci @ydeigin
Quoted tweet unavailable

Copy as image

Copied to clipboard!

Holtz @Biorealism
@EmaNymton90 @gjvdkamp @TWenseleers @jbloom_lab See also @DavidBahry https://zenodo.org/record/7016143#.ZBuvwqTRVkw

Copy as image

Copied to clipboard!

Holtz @Biorealism
@VeritasVincit5 @mbalter @EmaNymton90 @TWenseleers @BiophysicsFL Yes, see also @DavidBahry. https://zenodo.org/record/7016143#.ZBuvwqTRVkw

Copy as image

Copied to clipboard!

Holtz @Biorealism
In early October 2019 there was evidence of a similar kind in Wuhan. Reduced road traffic, roadblocks around the Wuhan Institute of Virology (WIV) & loss of phone signals around WIV suggested a major incident had occurred, estimated to have taken place between 6 & 11 October 2019

Copy as image

Copied to clipboard!

Holtz @Biorealism
@EmaNymton90 @TWenseleers Note Worobey et al. and Crits-Christoph et al. omit the toilets from their maps. @BiophysicsFL https://zenodo.org/record/7212687

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @R_H_Ebright @Dr_Al911 "Science is the new medieval church. Those who are popes of it censor at their will."

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @AndyMLinn @Debunk_the_Funk @FHeijblom Epidemiologist Professor Raina MacIntyre notes some of the parallels with US intelligence and Sverdlovsk. Hopefully we'll find out more either way now it's been declassified.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@sarahknapton That fits with excess death data per @scotub. Also, accounts of athletes who became ill during the October 2019 military games, school postponements in November 2019. https://t.co/04Pzx7V5cX
Holtz @Biorealism
: @sarahknapton @scotub See also @Globalbiosec

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @sarahknapton That fits with excess death data per @scotub. Also, accounts of athletes who became ill during the October 2019 military games, school postponements in November 2019.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@NovelVirusGuy @OdysseyBohemian @virologyanon @firasd @NateSilver538 What kind of evidence do you think we would already have? It will obviously be good to see what Intel the FBI is relying on. There is some that is suggestive of a lab shutdown in October 2019.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @NovelVirusGuy @OdysseyBohemian @virologyanon @firasd @NateSilver538 There was also the problem Shan-Lu Liu identified that the Wuhan Institute of Virology had many bat samples not yet worked out or results published.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @Cosby @ggronvall @NateSilver538 a day. Michael Lin notes that the earliest known sequences actually predate the market sequences.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @Cosby @ggronvall @NateSilver538 The lead WHO investigator Peter Ben Embarek acknowledges there were likely thousands of cases in December 2019. The sampling focused on those with the link to the market. WHO and the Taiwanese CECC don't accept market origin as there were likely much earlier cases.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@NovelVirusGuy @virologyanon @firasd @NateSilver538 It may have. We don't know where the index case was. The lead WHO investigator Peter Ben Embarek has said there were likely thousands of cases in Wuhan by December 2019. Sampling focused on the market. https://vbruttel.substack.com/p/the-strongest-evidence-yet-that-major?utm_source=twitter&utm_campaign=auto_share&r=1r7eig

Copy as image

Copied to clipboard!

Holtz @Biorealism
@virologyanon @NovelVirusGuy @firasd @NateSilver538 The Wuhan Institute of Virology was serviced by Line 2 of the Wuhan Metro System, which is adjacent to the Huanan Seafood market. WHO and the Taiwanese CECC don't accept market origin as there were likely much earlier cases.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@dkupiecki @quay_dr @stevenemassey @humblesci @Daoyu15 @ydeigin That's not the peer review. Did you have any views on the substance of the paper?

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Two_Pilgrims @NateSilver538 The Chinese want to argue it arose elsewhere. They don't support the market theory ( although initially thought it was plausible). They refuse to consider the lab origin scenario. https://t.co/7d00Yw2kjA
Holtz @Biorealism
: @Two_Pilgrims @NateSilver538 Dr Steven Quay explained the conflicting goals of these groups.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@wwwojtekk @BiophysicsFL Unsurprising. Thorp has also used his position to prevent debate regarding the origins of SARS-CoV-2. https://www.minerva.no/angus-dalgleish-birger-sorensen-coronavirus/the-fight-for-a-controversial-article/362519

Copy as image

Copied to clipboard!

Holtz @Biorealism
@pmddomingos @hholdenthorp @Magda_Skipper @ScienceMagazine Thorp's tweets show apparent bias against the possibility Sars-CoV-2 has a lab origin. It also transpired he rejected a paper by Norwegian virologist Birger Sørensen that contradicted his view on the basis it was critical of a paper in another journal. https://www.minerva.no/angus-dalgleish-birger-sorensen-coronavirus/the-fight-for-a-controversial-article/362519

Copy as image

Copied to clipboard!

Holtz @Biorealism
@PatrickSSte @mattwridley "Everyone knows it came from the Wuhan Institute of Virology"

Copy as image

Copied to clipboard!

Copy as image

Copied to clipboard!

Holtz @Biorealism
@chasewnelson @science @edwardcholmes And in terms of the toilets their Figure 1 doesn't show them. A preprint by @BiophysicsFL @humblesci and others sets out where they were. https://zenodo.org/record/7212687#.ZBtR96TRVkw

Copy as image

Copied to clipboard!

Holtz @Biorealism
@WallstreetRambo @zeynep About what? WHO and the Taiwanese CECC also consider there are cases prior to the market ones we know of. Michael Lin notes there are sequences that predate the market also.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Fruitopia5 @zeynep Maybe 20 million people have died and there were specific warnings from the likes of Marc Lipsitch and Carl T Bergstrom that lifting the moratorium on gain-of-function research on potential pandemic pathogens like SARS in 2017 risked a pandemic that would kill millions.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Michael26457210 @DougJBalloon Michael Lin also noted there are sequences that predate the market sequences.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @CastleRybread @DougJBalloon only about 60% sure. Basically the same as Mike Farzan's assessment even before it came to light the Wuhan Institute of Virology was part of a proposal to add furin cleavage sites into novel SARS-related bat coronaviruses.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @excellent__s @DougJBalloon Epidemiologist Professor Raina MacIntyre notes in her recent book that as with Sverdlovsk there was evidence of a lab shut down at the Wuhan Institute of Virology. Hopefully we will see more in relation to this now Biden has declassified the intelligence.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@excellent__s @DougJBalloon Curious as to what evidence is being referred to? WHO and the Taiwanese CECC don't accept market origin as there were likely much earlier cases. As Michael Lin notes, there are sequences that predate the market sequences. https://t.co/EkEyKUAmlK
Holtz @Biorealism
: @excellent__s @DougJBalloon From the outset lab origin has been seen as likely given the features of the virus and location of the outbreak in the same city as a US funded Institute that was teaching bat coronaviruses to infect human cells. There were ~40,000 wet markets in China in 2019.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@excellent__s @DougJBalloon Curious as to what evidence is being referred to? WHO and the Taiwanese CECC don't accept market origin as there were likely much earlier cases. As Michael Lin notes, there are sequences that predate the market sequences.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@mikeydoubled @zeynep That fits with excess death data per @scotub. https://t.co/5BN594gNK1
Holtz @Biorealism
: @mikeydoubled @zeynep @scotub Michael Lin also noted evidence of sequences basal to those found at the market.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @mikeydoubled @zeynep That fits with excess death data per @scotub.

Copy as image

Copied to clipboard!

Holtz @Biorealism
Professor Raina MacIntyre: My own research team, using the artificial intelligence driven system EPIWATCH...showed a signal for COVID in mid-November 2019. It also revealed evidence of media censorship, with the term 'SARS' redacted from the headlines of news stories.

Copy as image

Copied to clipboard!

Holtz @Biorealism
During Sverdlovsk, US intelligence agencies...analyzing the incident using satellite and other intelligence...correctly concluded that it was an unnatural outbreak - only to be overruled by the scientific experts.

Copy as image

Copied to clipboard!

Holtz @Biorealism
Professor Raina Macintyre: In case after case...health experts have demonstrated an inability or unwillingness to consider unnatural origins of epidemics. They have used extreme information warfare to create a narrative to support their case...

Copy as image

Copied to clipboard!

Holtz @Biorealism
@JamieMetzl And Western scientists and journals have circled the wagons to protect their interests.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@TravAlvord @CharlesRixey @UnbiasedPhd @WogPogReal @EthicalSkeptic @TyCardon @Fynnderella1 @Jikkyleaks @JesslovesMJK @DrLiMengYAN1 @SteveDeaceShow @DeaceOnline @NestCommander @KimDotcom @KimIversenShow @SomeB1tchIKnow @alykhansatchu @asrayagiriraj @breakfast_dogs That was after considerable political pressure. Sir Richard Dearlove has commented on how the efforts to block publications that argued for lab origin is an "absolute scandal".

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Ray_Grant_ @JanKlimkowski @Rebecca21951651 @stuartjdneil @R_H_Ebright @mbalter @natashaloder @emilyakopp @EmaNymton90 @KatherineEban @fayeflam @sciencecohen @hholdenthorp @WashburneAlex @Ayjchan @alisonannyoung @JamieMetzl Jesse Bloom on the work proposed under the NIAID grant. https://theintercept.com/2021/11/03/coronavirus-research-ecohealth-nih-emails/

Copy as image

Copied to clipboard!

Holtz @Biorealism
@henri_mourant @tiburke @NateSilver538 Thanks, then why say "[h]owever the genetic data irrefutably show that SARS-COV-2 is not derived from any previously used virus backbone" and reference a 2014 paper? Would you accept that is somewhat odd?

Copy as image

Copied to clipboard!

Holtz @Biorealism
@henri_mourant @tiburke @NateSilver538 ??

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @RobertC26440604 @NateSilver538 The argument for lab origin is basically the features of the virus are consistent with the work WIV was undertaking and it emerged in Wuhan. That was observed even before the DEFUSE proposal to add furin cleavage sites into novel SARS-related bat coronaviruses came to light.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @RobertC26440604 @NateSilver538 For example, Michael Lin noted the other day that the earliest sequences predate those at the market.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Two_Pilgrims @NateSilver538 The Chinese want to argue it arose elsewhere. They don't support the market theory ( although initially thought it was plausible). They refuse to consider the lab origin scenario.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@tiburke @NateSilver538 Unfortunately it's damaged the credibility of some of those journals that Proximal Origin with its definitive conclusions (citing a 2014 paper on known backbones) was published while papers arguing for lab origin were desk rejected.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@AtomicAdMan @NateSilver538 WHO and the Taiwanese CECC don't consider market origin likely as there were earlier cases. Michael Lin notes that there are earlier sequences to those found in the market.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@henri_mourant @nytimes Thanks. Have you seen this criticism of the report?

Copy as image

Copied to clipboard!

Holtz @Biorealism
@PaulBisceglio @TheAtlantic @KatherineJWu Professor Jesse Bloom: human Sars-CoV-2 infection started no later than November so we have to be circumspect about environmental samples from Jan 2020. https://t.co/pBOTIrIZXd
Holtz @Biorealism
: @PaulBisceglio @TheAtlantic @KatherineJWu Michael Lin makes the important point there are sequences that predate those at the market. In other words, the market isn't the source of the outbreak.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@PaulBisceglio @TheAtlantic @KatherineJWu Alina Chan makes an important point - the samples were processed in such a way that human genetic material was removed. https://t.co/Ed2oUhDDuZ
Holtz @Biorealism
: @PaulBisceglio @TheAtlantic @KatherineJWu Professor Jesse Bloom: human Sars-CoV-2 infection started no later than November so we have to be circumspect about environmental samples from Jan 2020.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@PaulBisceglio @TheAtlantic @KatherineJWu Alina Chan makes an important point - the samples were processed in such a way that human genetic material was removed.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@JonesKeto @nytimes Thanks. Alina Chan notes samples were processed in such a way that human genetic material was removed. @SherylNYT

Copy as image

Copied to clipboard!

Holtz @Biorealism
@jbloom_lab Is there a reason why they omit the toilets from figure 1? https://zenodo.org/record/7212687#.ZBpynqSYZkw

Copy as image

Copied to clipboard!

Holtz @Biorealism
@nytimes An important point in this 🧵
Quoted tweet unavailable

Copy as image

Copied to clipboard!

Holtz @Biorealism
@nytimes Alina Chan: Another serious case of the Proximal Origin authors not carefully reading the methods section of the Chinese CDC's paper whose data they used in their #OriginOfCovid analysis. Samples were processed in a way such that human genetic material was removed.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@desktopcarl @nytimes Two mutations apart? Also, if I recall correctly they discarded intermediates in a seemingly ad hoc manner @BiophysicsFL?

Copy as image

Copied to clipboard!

Holtz @Biorealism
@desktopcarl @nytimes I think that's questionable. See comments by Michael Lin regarding sequences basal to the A-B lineage split off.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@nytimes Michael Lin makes the important point there are sequences that predate those at the market. In other words, the market isn't the source of the outbreak.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@MarionKoopmans @WashburneAlex Any idea why they omit the toilets from figure 1? Looks like they are misleading by omission. https://zenodo.org/record/7169296/export/schemaorg_jsonld

Copy as image

Copied to clipboard!

Holtz @Biorealism
@AdoredTV @NwaigboOdera @nerdtechgasm Thanks, there are few things to say about that article but fundamentally Garry has never even addressed the point he raised himself. How can SC2 be identical to RaTG13 (which WIV had) aside from the 12nt insertion that adds the furin site? It's never been explained.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@AdoredTV @NwaigboOdera @nerdtechgasm It doesn't prove anything, but it suggests this scenario was more likely (even predicted) than you might think given most viruses resulting from zoonotic spillover. And as Petrovsky and Winkler note, the initial binding affinity to human cells is unlike other zoonotic viruses.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @AdoredTV @NwaigboOdera @nerdtechgasm This specific scenario was warned about. Then you have a Sars-related bat coronavirus outbreak to occur in Wuhan, adapted to human cells right out the gate (in contrast to SARS1) where a US funded Institute was experimenting on how SrCVs can infect human cells.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@AdoredTV @NwaigboOdera @nerdtechgasm Also, it's significant that the Wuhan Institute of Virology sampled in Laos where the Banal sequences were found. They also sampled in Yunnan where the other closest relatives to SARS-CoV-2 are found. https://t.co/KFuXqWwZBT
Holtz @Biorealism
: @AdoredTV @NwaigboOdera @nerdtechgasm The furin site with its unusual codon usage has always been a puzzle. Per FOIA information it's now known it was seen as potentially engineered. That was even before the DEFUSE proposal to introduce furin cleavage sites into novel SARS-related bat coronaviruses came to light.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@AdoredTV @NwaigboOdera @nerdtechgasm The senior author on the Banal papers, Marc Eloit notes the furin site remains unexplained and may have resulted from serial passage in a lab. Mike Farzan suggested the same mechanism at the outset. https://t.co/PhAqFfYwDV
Holtz @Biorealism
: @AdoredTV @NwaigboOdera @nerdtechgasm Also, it's significant that the Wuhan Institute of Virology sampled in Laos where the Banal sequences were found. They also sampled in Yunnan where the other closest relatives to SARS-CoV-2 are found.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@AdoredTV @NwaigboOdera @nerdtechgasm The senior author on the Banal papers, Marc Eloit notes the furin site remains unexplained and may have resulted from serial passage in a lab. Mike Farzan suggested the same mechanism at the outset.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@AdoredTV @nerdtechgasm Botao & Lei Xiao suggested lab origin was likely on 6 Feb 2020 because the nearest relatives were ~900km away in areas the Wuhan Institute of Virology sampled. Fang Chi-tai gave a lecture noting unusual features of the furin site before having to disavow. https://nymag.com/intelligencer/article/coronavirus-lab-escape-theory.html

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Science54900201 @WendyOrent @ras_nielsen @WashburneAlex Note researchers at the Chinese Academy of Sciences have argued the Pekar et al. overstate their conclusions based on limited data and unrealistic simulations. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9128337/

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Florin_Uncovers @stgoldst @JoshRosenau Chan has repeatedly poured cold water on bioweapon claims.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@mattwridley @MichaelWorobey There is also a paper from researchers at the Chinese Academy of Sciences who were highly critical of the preprints by Worobey et al and Pekar et al. arguing for market origin. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9128337/

Copy as image

Copied to clipboard!

Holtz @Biorealism
@mbalter @Medium @Ayjchan There is also a paper from researchers at the Chinese Academy of Sciences who were highly critical of the preprints by Worobey et al and Pekar et al. arguing for market origin. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9128337/

Copy as image

Copied to clipboard!

Holtz @Biorealism
@ChuckPaulen @dmoulding @quay_dr @humblesci @joshrogin Interesting, I hadn't seen that comment from Farrar that he was thinking the furin site was the result of cell culture passage. Similar to Mike Farzan's observation.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@AshleyRindsberg @BugRib @thackerpd @DisInfoChron @HansMahncke @TheDragonFeeder @joshrogin @mbalter @peterpham @hkakeya @Muller_Lab @Bryce_Nickels The amazing thing is thanks to FOIA information we now know the furin site in SARS-CoV-2 was rumored by experts to be engineered from the outset (in private). This was even before the DEFUSE proposal to add furin sites into novel SARS-related bat coronaviruses came to light.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @sirhlyon @SteveBigpond @stuartjdneil @breakfast_dogs @WashburneAlex @Florin_Uncovers @R_H_Ebright Newman on this. He could also mention the unusual codon usage.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @sirhlyon @SteveBigpond @stuartjdneil @breakfast_dogs @WashburneAlex @Florin_Uncovers @R_H_Ebright As have the Lancet Covid19 Commission & WHO. Michael Ryan said all hypotheses remain open after the fanfare of the papers arguing for market origin last year. Apparently, they consider there were earlier cases so don't think the market was the origin, nor does the Taiwanese CDC.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @sirhlyon @SteveBigpond @stuartjdneil @breakfast_dogs @WashburneAlex @Florin_Uncovers @R_H_Ebright Roger Brent also noted that if you canvassed subspecialties of biologists who weren't "emotionally and professionally invested in issues surrounding research on viral pathogens" the response may be very different.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@sirhlyon @SteveBigpond @stuartjdneil @breakfast_dogs @WashburneAlex @Florin_Uncovers @R_H_Ebright Unless you have an anonymous survey I would take your 90% claim with a grain of salt given the political circumstances favor self-censorship. Richard A. Muller found his virology colleagues were afraid to even discuss the lab origin scenario. https://t.co/qKk1UO1fzR
Holtz @Biorealism
: @sirhlyon @SteveBigpond @stuartjdneil @breakfast_dogs @WashburneAlex @Florin_Uncovers @R_H_Ebright We see that with the FOIA correspondence researchers who have said natural origin is likely privately considered lab origin was likely. Liu and Weiss omitted these concerns about the furin site being engineered from the paper they were proofing & never raised them publicly.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@sirhlyon @SteveBigpond @stuartjdneil @breakfast_dogs @WashburneAlex @Florin_Uncovers @R_H_Ebright Unless you have an anonymous survey I would take your 90% claim with a grain of salt given the political circumstances favor self-censorship. Richard A. Muller found his virology colleagues were afraid to even discuss the lab origin scenario.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@emilyakopp DiNanno's team obtained a classified report prepared by the Lawrence Livermore National Laboratory's Z Division, dated May 27 2020, which made the case that Covid19 may have originated as a result or synthetic and "serial passage" gain-of-function research.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@RogerMarshallMD @joshrogin @ENERGY @StateDept @Livermore_Lab DiNanno's team obtained a classified report prepared by the Lawrence Livermore National Laboratory's Z Division, dated May 27 2020, which made the case that Covid19 may have originated as a result or synthetic and "serial passage" gain-of-function research.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@radsci @RadCentrism @quay_dr @ydeigin Not on bat coronaviruses? The Wuhan Institute of Virology was doing the studies on Understanding the Risk of Bat Coronavirus Emergence for the NIAD and also proposing the use infectious cloning to make recombinant SARS coronaviruses for CAS.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@radsci @RadCentrism @quay_dr @ydeigin Why Wuhan though? The adaptation to human cells could also be due to serial passage which I understand WIV was undertaking with bat coronaviruses. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)02019-5/fulltext

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @radsci @RadCentrism @quay_dr @ydeigin cleavage sites into novel SARS-related bat coronaviruses. It was rumored to be engineered just from the nature of the furin site even before that proposal came to light.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@radsci @RadCentrism @quay_dr @ydeigin In a court of law robust inferences are made all the time where scientists or medical experts say something "may have" occurred. In this case there are a number of factors that in combination are more readily explained by lab origin. Location, features of the virus, including

Copy as image

Copied to clipboard!

Holtz @Biorealism
@JamieMetzl @WashburneAlex @COVIDSelect DiNanno's team obtained a classified report prepared by the Lawrence Livermore National Laboratory's Z Division, dated May 27 2020, which made the case that Covid19 may have originated as a result or synthetic and "serial passage" gain-of-function research.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@R_H_Ebright @gdemaneuf DiNanno's team obtained a classified report prepared by the Lawrence Livermore National Laboratory's Z Division, dated May 27 2020, which made the case that Covid19 may have originated as a result or synthetic and "serial passage" gain-of-function research.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@quay_dr @ydeigin DiNanno's team obtained a classified report prepared by the Lawrence Livermore National Laboratory's Z Division, dated May 27 2020, which made the case that Covid19 may have originated as a result or synthetic and "serial passage" gain-of-function research.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @fielding @gregggonsalves @NPR WHO has also maintained all hypotheses remain on the table and aren't convinced market origin is likely.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @slackerbarista @NateFair123 @AlexMLeo @Halalcoholism @AliceFromQueens This is an anonymous account from a Dr in Wuhan regarding cases coming in November 2019. From Markson's 'What Really Happened in Wuhan'. A slightly sensationalist title but it has some interesting material about the early stage of the outbreak, interviews with Petrovsky & others.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@slackerbarista @NateFair123 @AlexMLeo @Halalcoholism @AliceFromQueens It's hard to say. This is a regime that went to extraordinary lengths to suppress news of the outbreak itself (journalists imprisoned, doctors reprimanded). They apparently didn't reveal there was human to human transmission and have refused to allow any real investigation.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @slackerbarista @NateFair123 @AlexMLeo @Halalcoholism @AliceFromQueens Ultimately it might never be firmly resolved either way unless a whistleblower emerges, something the late Phil Russell suggested to James Le Duc (who trained WIV staff) early on.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@slackerbarista @NateFair123 @AlexMLeo @Halalcoholism @AliceFromQueens We also see that with the FOIA correspondence researchers who have said natural origin is likely privately considered lab origin was likely. Liu and Weiss omitted these concerns about the furin site from the paper they were proofing and never raised them publicly. https://t.co/0SRzk9jiwR
Holtz @Biorealism
: @slackerbarista @NateFair123 @AlexMLeo @Halalcoholism @AliceFromQueens There is also censorship by the PRC which impacts researchers. Chinese researchers Botao and Lei Xiao were amongst the first to suggest lab origin was likely in a preprint on 6 February 2020. It disappeared Fang Chi-tai gave a lecture he disavowed. https://nymag.com/intelligencer/article/coronavirus-lab-escape-theory.html

Copy as image

Copied to clipboard!

Holtz @Biorealism
@slackerbarista @NateFair123 @AlexMLeo @Halalcoholism @AliceFromQueens You're right if you look at published articles they have tended to focus on natural origin scenarios. The problem is given the political circumstances there is evidence of self-censorship. Richard A. Muller found his virology colleagues were afraid to even discuss lab origin. https://t.co/h9y3rMZPNp
Holtz @Biorealism
: @slackerbarista @NateFair123 @AlexMLeo @Halalcoholism @AliceFromQueens We also see that with the FOIA correspondence researchers who have said natural origin is likely privately considered lab origin was likely. Liu and Weiss omitted these concerns about the furin site from the paper they were proofing and never raised them publicly.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @slackerbarista @NateFair123 @AlexMLeo @Halalcoholism @AliceFromQueens You're right if you look at published articles they have tended to focus on natural origin scenarios. The problem is given the political circumstances there is evidence of self-censorship. Richard A. Muller found his virology colleagues were afraid to even discuss lab origin.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @GOPoversight @RepBradWenstrup @RepJamesComer @ENERGY @StateDept @FBI @hholdenthorp @JMinImmunoland @ScienceMagazine @NatureMedicine Even the Perspective chosen to comment on Worobey et. and Pekar et al. suggests this was the editorial view and alternative viewpoints weren't going to be aired. @AldertonBiol

Copy as image

Copied to clipboard!

Holtz @Biorealism
@GOPoversight @RepBradWenstrup @RepJamesComer @ENERGY @StateDept @FBI It may be worth asking former M16 Head Sir Richard Dearlove to testify on the academic journals he said "behaved in a totally outrageous fashion" to stop a paper supportive of lab origin from being published. This gatekeeping is a major problem.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @COVIDSelect @RepBradWenstrup @hholdenthorp @JMinImmunoland @NatureMedicine Sir Richard Dearlove former head of M16 says that the moment the journals realised the paper presented an opposing view from the natural origin thesis, they "behaved in a totally outrageous fashion to stop it from being published."

Copy as image

Copied to clipboard!

Holtz @Biorealism
@slackerbarista @NateFair123 @AlexMLeo @Halalcoholism @AliceFromQueens Nikolai Petrovsky and David Winkler, two of the authors, have elaborated on how surprising that is. It is consistent with serial passage in humanized mice which Mike Farzan, Marc Eloit and others have suggested. https://t.co/MYbcRiAlSR
Holtz @Biorealism
: @slackerbarista @NateFair123 @AlexMLeo @Halalcoholism @AliceFromQueens See discussion. The Wuhan Institute of Virology had hACE2 binding and humanized mouse infection with synthetic recombinant bat coronaviruses in 2019. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)02019-5/fulltext

Copy as image

Copied to clipboard!

Holtz @Biorealism
@slackerbarista @NateFair123 @AlexMLeo @Halalcoholism @AliceFromQueens Apologies I hadn't read further up the thread. There are a number of papers that support lab origin or suggest there are unusual features that should be investigated. The binding affinity to human cells & lack of signs of selection to optimize this. https://t.co/qTpJMaR0Am https://t.co/IQCpafc1XF
Holtz @Biorealism
: @slackerbarista @NateFair123 @AlexMLeo @Halalcoholism @AliceFromQueens Nikolai Petrovsky and David Winkler, two of the authors, have elaborated on how surprising that is. It is consistent with serial passage in humanized mice which Mike Farzan, Marc Eloit and others have suggested.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@slackerbarista @NateFair123 @AlexMLeo @Halalcoholism @AliceFromQueens Apologies I hadn't read further up the thread. There are a number of papers that support lab origin or suggest there are unusual features that should be investigated. The binding affinity to human cells & lack of signs of selection to optimize this. https://www.nature.com/articles/s41598-021-92388-5

Copy as image

Copied to clipboard!

Holtz @Biorealism
@NateFair123 @slackerbarista @AlexMLeo @Halalcoholism @AliceFromQueens Another peer reviewed paper that is highly critical of Worobey et al and Pekar et al. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9128337/

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biol4Ever @angie_rasmussen @ScienceMagazine @franciscodeasis There is also a peer reviewed paper from researchers at the Chinese Academy of Sciences who were highly critical of Worobey et al and Pekar et al. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9128337/

Copy as image

Copied to clipboard!

Holtz @Biorealism
@eupseiphos @gendal @Ayjchan @mattwridley Covers some of the work by her fellow Australian scientists well :-)

Copy as image

Copied to clipboard!

Holtz @Biorealism
@TheJakeSchmidt @JHWeissmann @DavidBahry @gdemaneuf Nikolai Petrovsky and David Winkler noted humans topped the list for binding affinity from the outset and there was little sign of further selection in that direction. This would be consistent with serial passage in humanized mice something WIV was doing. https://t.co/qTpJMaR0Am https://t.co/vKYX0IdPzj
Holtz @Biorealism
: @TheJakeSchmidt @JHWeissmann @DavidBahry @gdemaneuf https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)02019-5/fulltext

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @TheJakeSchmidt @JHWeissmann @DavidBahry @gdemaneuf Nikolai Petrovsky and David Winkler noted humans topped the list for binding affinity from the outset and there was little sign of further selection in that direction. This would be consistent with serial passage in humanized mice something WIV was doing. https://www.nature.com/articles/s41598-021-92388-5

Copy as image

Copied to clipboard!

Holtz @Biorealism
@reluctantlyjoe @SaskiaPopescu OK, but maybe you could lead by example? https://t.co/LxSUdVmnN2
Holtz @Biorealism
: @reluctantlyjoe @SaskiaPopescu This is flat out bullying of an Asian female biologist. Ebright is open to criticism but it's a bit rich if you're behaving like this yourself, no?

Copy as image

Copied to clipboard!

Holtz @Biorealism
@reluctantlyjoe @SaskiaPopescu OK, but maybe you could lead by example?

Copy as image

Copied to clipboard!

Holtz @Biorealism
@ZacBissonnette Coauthored by Francis Collins who was head of the NIH until 2021. Collins was a key figure in trying to dismiss lab origin as a conspiracy.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@bed__wards @SaskiaPopescu Roger Brent: if you canvassed any other sub-specialties of biologists who are not emotionally and professionally invested invested in issues surrounding research on viral pathogens, I suspect you would get a very different 'wide scientific consensus'.

Copy as image

Copied to clipboard!

Holtz @Biorealism
Michael Eisen on the need to strengthen lab safety and limit future human made pandemics.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@BCNThomson @michaelzlin @MJnanostretch You don't think the type of work proposed in DEFUSE could have lead to SC2? Off hand, Jack Nunberg, Justin Kinney, @R_H_Ebright have said it could have done. https://i.stuff.co.nz/national/health/coronavirus/300424689/revealed-wuhan-and-us-scientists-planned-to-create-new-coronaviruses

Copy as image

Copied to clipboard!

Holtz @Biorealism
@mattyglesias An extreme example being Jim Jones and the People's Temple.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Castdeath97 @DavidBahry @RiverTamYDN @gdemaneuf Note the furin site with its particular codon usage has always been a significant piece of evidence. As Liu notes, it was rumored to be engineered. This was even before it came to light WIV was part of a proposal to add furin cleavage sites into novel SrCVs.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@mbalter @emilyakopp @angie_rasmussen @Ayjchan Which is why it's so jarring seeing their private correspondence showing they know the furin site makes lab origin very plausible indeed.

Copy as image

Copied to clipboard!

Holtz @Biorealism
Peter Ben Embarek: we could only discuss lab origin in the report "on the condition we didn't recommend any specific studies to further that hypothesis."
Quoted tweet unavailable

Copy as image

Copied to clipboard!

Holtz @Biorealism
@JohnMolka @MarionKoopmans That would make them look more reasonable, but they aren't interested in opposing views. The key challenge lead investigator Peter Ben Embarek found was that China has refused to allow any investigation of the lab origin scenario. Hence the need to investigate US sources.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Ayjchan Unusual codon usage too, "CGG is the codon widely used in labs for Arg for over a decade."

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @HL3133 @Sri_Baqri @CellCellPress @stuartjdneil A number of zoonotic spillover supporters have doubts about whether this paper shows a furin cleavage site.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@emilyakopp Gary Whittaker doubts that Stuart Neil's new paper shows a furin cleavage site. https://t.co/sKq183voKS
Holtz @Biorealism
: @emilyakopp Some others who share Gary Whittaker's doubts about the furin cleavage site in Stuart Neil's new paper.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@BiophysicsFL @Rebecca21951651 @REGENETARIANISM @emilyakopp @WashburneAlex @R_H_Ebright @HansMahncke @mlipsitch @T_Inglesby @ggronvall @MarionKoopmans @gabbystern @mvankerkhove @quay_dr @Ayjchan @natashaloder @fayeflam Even Gary Whittaker isn't convinced it's a furin cleavage site. https://t.co/oMHaDNBTzW
Holtz @Biorealism
: @BiophysicsFL @Rebecca21951651 @REGENETARIANISM @emilyakopp @WashburneAlex @R_H_Ebright @HansMahncke @mlipsitch @T_Inglesby @ggronvall @MarionKoopmans @gabbystern @mvankerkhove @quay_dr @Ayjchan @natashaloder @fayeflam Some others who share Gary Whittaker's doubts about the furin cleavage site in Stuart Neil's new paper.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@TimSmit17 @Jikkyleaks @Kevin_McKernan Even Gary Whittaker doesn't think it shows a furin cleavage site.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@emilyakopp Gary Whittaker doubts that Stuart Neil's new paper shows a furin cleavage site.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@BiophysicsFL @Rebecca21951651 @REGENETARIANISM @emilyakopp @WashburneAlex @R_H_Ebright @HansMahncke @mlipsitch @T_Inglesby @ggronvall @MarionKoopmans @gabbystern @mvankerkhove @quay_dr @Ayjchan @natashaloder @fayeflam Even Gary Whittaker isn't convinced it's a furin cleavage site.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Denachtzuster1 @Sri_Baqri @CellCellPress @stuartjdneil @john_bumblebee Even supporters of the unlikely zoonotic spillover theory have problems with this paper.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@abhishek_s_1 @DialecticBio @DavidBahry @acritschristoph @thebirdmaniac That's in the US, but recall Chinese researchers Botao and Lei Xiao were amongst the first to argue lab origin was likely in February 2020 before the PRC gag order. Fang Chi-tai disavowed his comments. https://t.co/knDU7ipeoG https://t.co/5hAWr9zpTp
Holtz @Biorealism
: @abhishek_s_1 @DialecticBio @DavidBahry @acritschristoph @thebirdmaniac Another example is people who have written papers arguing lab origin is unlikely while omitting arguments and concerns that they held privately. You would need an anonymous survey to get a true gauge on expert opinion.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@abhishek_s_1 @DialecticBio @DavidBahry @acritschristoph @thebirdmaniac There's also evidence that some are reluctant to discuss the issue at all as Richard A Muller found. Virology colleagues he approached were afraid to discuss the lab origin scenario. https://t.co/opL2cWd7hy
Holtz @Biorealism
: @abhishek_s_1 @DialecticBio @DavidBahry @acritschristoph @thebirdmaniac That's in the US, but recall Chinese researchers Botao and Lei Xiao were amongst the first to argue lab origin was likely in February 2020 before the PRC gag order. Fang Chi-tai disavowed his comments. https://nymag.com/intelligencer/article/coronavirus-lab-escape-theory.html

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @abhishek_s_1 @DialecticBio @DavidBahry @acritschristoph @thebirdmaniac There's also evidence that some are reluctant to discuss the issue at all as Richard A Muller found. Virology colleagues he approached were afraid to discuss the lab origin scenario.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@CulturalRadical @jorymicah A market origin is also inconsistent with the observation of Nikolai Petrovsky and David Winkler that humans topped the list for binding affinity from the outset. https://t.co/qTpJMaR0Am https://t.co/p7ldAhE4h0
Holtz @Biorealism
: @CulturalRadical @jorymicah The binding affinity to human cells from the outset and lack of evidence of antibodies (which were seen in animal traders with SARS1) is consistent with serial passage in humanized mice, something Wuhan Institute of Virology had. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)02019-5/fulltext

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @CulturalRadical @jorymicah A market origin is also inconsistent with the observation of Nikolai Petrovsky and David Winkler that humans topped the list for binding affinity from the outset. https://www.nature.com/articles/s41598-021-92388-5

Copy as image

Copied to clipboard!

Holtz @Biorealism
@lab_leak @Sri_Baqri @CellCellPress @stuartjdneil Reminds me MERS "insert' or recombination in contaminated cell lines was proposed by Bernd Kaina. https://t.co/yFc2woH3ZS https://t.co/37f6TyjpoY
Holtz @Biorealism
: @lab_leak @Sri_Baqri @CellCellPress @stuartjdneil

Copy as image

Copied to clipboard!

Holtz @Biorealism
@lab_leak @Sri_Baqri @CellCellPress @stuartjdneil Reminds me MERS "insert' or recombination in contaminated cell lines was proposed by Bernd Kaina. https://iv.iiarjournals.org/content/35/3/1313

Copy as image

Copied to clipboard!

Holtz @Biorealism
@HL3133 @Sri_Baqri @CellCellPress @stuartjdneil Even those sympathetic to the unlikely zoonotic spillover scenario are unconvinced.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@DavidBahry @acritschristoph @thebirdmaniac Shan-Lu Liu: "I completely agree with you, but rumor says that furin site may be engineered. Importantly, the virus RNA sequence around the furin site (288 nt), before and after, has 6.6% differences, but with no amino acid changes at all."

Copy as image

Copied to clipboard!

Holtz @Biorealism
@abhishek_s_1 @DavidBahry @acritschristoph @thebirdmaniac Mike Farzan and Marc Eloit have raised the possibility that serial passage in humanized mice played a role. That prospect is also discussed in this Lancet correspondence @ColinDavdButler. https://t.co/e7YhCE078V https://t.co/pUFUT944gK
Holtz @Biorealism
: @abhishek_s_1 @DavidBahry @acritschristoph @thebirdmaniac @ColinDavdButler In 2017, the Wuhan Institute of Virology also proposed to use infectious cloning to make recombinant SARS coronaviruses. We don't know what became of this as far as I know.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@abhishek_s_1 @DavidBahry @acritschristoph @thebirdmaniac Also, Nikolai Petrovsky and David Winkler observed humans topped the list for binding affinity from the outset. Very different to SARS1 or other zoonotic viruses. https://t.co/qTpJMaR0Am https://t.co/oWUFg7vKIX
Holtz @Biorealism
: @abhishek_s_1 @DavidBahry @acritschristoph @thebirdmaniac Mike Farzan and Marc Eloit have raised the possibility that serial passage in humanized mice played a role. That prospect is also discussed in this Lancet correspondence @ColinDavdButler. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)02019-5/fulltext

Copy as image

Copied to clipboard!

Holtz @Biorealism
@abhishek_s_1 @DavidBahry @acritschristoph @thebirdmaniac Also, Nikolai Petrovsky and David Winkler observed humans topped the list for binding affinity from the outset. Very different to SARS1 or other zoonotic viruses. https://www.nature.com/articles/s41598-021-92388-5

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Odettescuck @reluctantlyjoe @C_Kavanagh As legendary computational biologist Nick Patterson noted, it's too much of a coincidence SARS-CoV-2 emerged in Wuhan after the Wuhan Institute of Virology was part of a proposal to engineer and study a virus that would look remarkably like SARS-CoV-2. https://t.co/kmAfUvhD8s
Holtz @Biorealism
: @Odettescuck @reluctantlyjoe @C_Kavanagh Nikolai Petrovsky and David Winkler noted the binding affinity to humans from the outset is unlike SARS1 or other zoonotic viruses. https://www.nature.com/articles/s41598-021-92388-5

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Odettescuck @reluctantlyjoe @C_Kavanagh Not to mention humans topping the list for binding affinity or the furin site with no surrounding amino acid changes. It looked suspicious even before it was known the Wuhan Institute of Virology was part of a proposal to introduce furin cleavage sites into novel SrCVs. https://t.co/zoVvoWIFa4
Holtz @Biorealism
: @Odettescuck @reluctantlyjoe @C_Kavanagh As legendary computational biologist Nick Patterson noted, it's too much of a coincidence SARS-CoV-2 emerged in Wuhan after the Wuhan Institute of Virology was part of a proposal to engineer and study a virus that would look remarkably like SARS-CoV-2.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Odettescuck @reluctantlyjoe @C_Kavanagh Not to mention humans topping the list for binding affinity or the furin site with no surrounding amino acid changes. It looked suspicious even before it was known the Wuhan Institute of Virology was part of a proposal to introduce furin cleavage sites into novel SrCVs.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@mdc_martinus @lab_leak @MarionKoopmans Dr Roger Brent explained views on the origins of SARS-CoV-2 are likely to differ between those (like Koopmans) who are "emotionally and professionally invested in issues surrounding research on viral pathogens" and other biologists.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@WashburneAlex Michael Crichton called this Gell-Mann Amnesia effect. http://geer.tinho.net/crichton.why.speculate.txt

Copy as image

Copied to clipboard!

Holtz @Biorealism
@natashaloder Yes, Peter Ben Embarek basically acknowledged they couldn't study the lab origin scenario.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@JackDempsey2_2 @BiophysicsFL @NPR @FoodieScience @PeterDaszak The observation by Gray is also a reason why serial passage in humanized mice has been suggested as an explanation, as Sars-CoV-2 lacks the signs of early adaptation or antibodies with SARS1 & humans topped the list for binding affinity from the outset. https://t.co/e7YhCE078V https://t.co/m0GnArK463
Holtz @Biorealism
: @JackDempsey2_2 @BiophysicsFL @NPR @FoodieScience @PeterDaszak I would be curious to know if @FoodieScience considered approaching Nikolai Petrovsky or David Winkler about this feature which does appear more consistent with lab origin than the scenario Gray observed? https://www.nature.com/articles/s41598-021-92388-5

Copy as image

Copied to clipboard!

Holtz @Biorealism
@ashrrs @NPR The observation by Gray is also a reason why serial passage in humanized mice has been suggested as an explanation, as Sars-CoV-2 lacks the signs of early adaptation or antibodies with SARS1 & humans topped the list for binding affinity from the outset. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)02019-5/fulltext

Copy as image

Copied to clipboard!

Holtz @Biorealism
@JackDempsey2_2 @BiophysicsFL @NPR @FoodieScience @PeterDaszak The observation by Gray is also a reason why serial passage in humanized mice has been suggested as an explanation, as Sars-CoV-2 lacks the signs of early adaptation or antibodies with SARS1 & humans topped the list for binding affinity from the outset. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)02019-5/fulltext

Copy as image

Copied to clipboard!

Holtz @Biorealism
@franks_lawyer @berenddeboer Interesting, wasn't aware of this.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@jehrenreich @reluctantlyjoe @jbloom_lab @jbkinney @Biol4Ever @DavidBahry @gdemaneuf Dr Roger Brent observes that views on the origins of SARS-CoV-2 may be very different amongst subspecialties of biologists "who are not emotionally and professionally invested in issues surrounding research on viral pathogens." https://t.co/ux7qYmkbtw
Holtz @Biorealism
: @jehrenreich @reluctantlyjoe @jbloom_lab @jbkinney @Biol4Ever @DavidBahry @gdemaneuf I think that you may be right about some of the biases of lab origin supporters but have overlooked other biases that exist in this debate. Recall also Marc Lipsitch, Carl T Bergstrom and @R_H_Ebright warned against lifting the moratorium on GoF on pandemic potential pathogens.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@jehrenreich @reluctantlyjoe @jbloom_lab @jbkinney @Biol4Ever @DavidBahry @gdemaneuf Richard A. Muller found his virology colleagues were afraid to even discuss the lab origin scenario. https://t.co/kZL9d5tzg1
Holtz @Biorealism
: @jehrenreich @reluctantlyjoe @jbloom_lab @jbkinney @Biol4Ever @DavidBahry @gdemaneuf Dr Roger Brent observes that views on the origins of SARS-CoV-2 may be very different amongst subspecialties of biologists "who are not emotionally and professionally invested in issues surrounding research on viral pathogens."

Copy as image

Copied to clipboard!

Holtz @Biorealism
@jehrenreich @reluctantlyjoe @jbloom_lab @jbkinney @Biol4Ever @DavidBahry @gdemaneuf It's unlikely that Shan-Lu Liu or Mike Farzan were providing anything other than their unvarnished opinion here in private correspondence. I think lab leak critics overlook the massive incentives *against* supporting that theory for those in the field? https://t.co/pT9lGelx3C
Holtz @Biorealism
: @jehrenreich @reluctantlyjoe @jbloom_lab @jbkinney @Biol4Ever @DavidBahry @gdemaneuf Richard A. Muller found his virology colleagues were afraid to even discuss the lab origin scenario.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @jehrenreich @reluctantlyjoe @jbloom_lab @jbkinney @Biol4Ever @DavidBahry @gdemaneuf It's unlikely that Shan-Lu Liu or Mike Farzan were providing anything other than their unvarnished opinion here in private correspondence. I think lab leak critics overlook the massive incentives *against* supporting that theory for those in the field?

Copy as image

Copied to clipboard!

Holtz @Biorealism
@danwalker9999 @reluctantlyjoe Especially when there were specific warnings to the NIH that lifting the moratorium on gain-of-function research on potential pandemic pathogens like SARS risked a pandemic that would kill millions.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@reluctantlyjoe Nikolai Petrovsky & David Winkler noted humans topped the list for binding affinity from the outset. Consistent with serial passage in humanized mice. Wuhan Institute of Virology had hACE2 binding and humanized mouse infection with synthetic recombinant bat coronaviruses in 2019. https://t.co/umwRVIRqu1
Holtz @Biorealism
: @reluctantlyjoe Farzan, Marc Eloit and various others have noted serial passage would explain some of the features such as the binding affinity from the outset in contrast to SARS1. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)02019-5/fulltext

Copy as image

Copied to clipboard!

Holtz @Biorealism
@reluctantlyjoe Recall in 2017, the likes of Marc Lipsitch and Carl T Bergstrom warned that lifting the moratorium on gain-of-function research on potential pandemic pathogens like SARS risked a pandemic that would kill millions. https://t.co/aJ2WRwaCle
Holtz @Biorealism
: @reluctantlyjoe Nikolai Petrovsky & David Winkler noted humans topped the list for binding affinity from the outset. Consistent with serial passage in humanized mice. Wuhan Institute of Virology had hACE2 binding and humanized mouse infection with synthetic recombinant bat coronaviruses in 2019.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@reluctantlyjoe I doubt that was the concern of Fang Chi-tai, Mike Farzan, Botao Xiao or Lei Xiao. The features of the virus, nature of the work the Wuhan Institute of Virology was undertaking and location of the outbreak always made lab origin a likely scenario. https://t.co/Sm7ebw3PIa
Holtz @Biorealism
: @reluctantlyjoe Recall in 2017, the likes of Marc Lipsitch and Carl T Bergstrom warned that lifting the moratorium on gain-of-function research on potential pandemic pathogens like SARS risked a pandemic that would kill millions.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@reluctantlyjoe I doubt that was the concern of Fang Chi-tai, Mike Farzan, Botao Xiao or Lei Xiao. The features of the virus, nature of the work the Wuhan Institute of Virology was undertaking and location of the outbreak always made lab origin a likely scenario.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@nativirod @mvankerkhove @WHO @DrTedros I think we can make a robust inference from the features of the virus, location of the outbreak and nature of the work the Wuhan Institute of Virology was involved with. The binding affinity to humans alone suggests serial passage in humanized mice. https://t.co/crCR5wSwZo
Holtz @Biorealism

Copy as image

Copied to clipboard!

Holtz @Biorealism
@nativirod @mvankerkhove @WHO @DrTedros I think we can make a robust inference from the features of the virus, location of the outbreak and nature of the work the Wuhan Institute of Virology was involved with. The binding affinity to humans alone suggests serial passage in humanized mice.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@hullalulu @RVirologist Nikolai Petrovsky and David Winkler noted humans topped the list for binding affinity from the start. Consistent with serial passage in humanized mice. https://t.co/uyWoEEWQm4
Holtz @Biorealism
: @hullalulu @RVirologist The Wuhan Institute of Virology had hACE2 binding and humanized mouse infection with synthetic recombinant bat coronaviruses in 2019 as far as I can gather. This would help explain the binding affinity to human cells seen from the outset. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)02019-5/fulltext

Copy as image

Copied to clipboard!

Holtz @Biorealism
@hullalulu @RVirologist Nikolai Petrovsky and David Winkler noted humans topped the list for binding affinity from the start. Consistent with serial passage in humanized mice.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@JamieMetzl @WHO In the meantime, people may draw a robust inference about the features of the virus, location of the outbreak and draw robust inferences about the origins of SARS-CoV-2.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@mvankerkhove @WHO In the meantime, it's reasonable to assume that it had a lab origin.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@JonPloug @HumeField @PeterDaszak @MarionKoopmans Sorry, but if anything Dr Tedros showed extraordinary courage in pushing back against "premature" efforts to dismiss lab origin. And rightly so given Peter Ben Embarek's revelation that the investigation was a sham. https://t.co/eyKXpRdm2n
Holtz @Biorealism
: @JonPloug @HumeField @PeterDaszak @MarionKoopmans The reality is Sars-CoV-2, with its binding affinity to human cells, furin site, codon usage, lack of other amino acid changes, distance to nearest relatives in areas WIV sampled, likely arose from a lab accident and the PRC was never going to cooperate in an investigation.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@JonPloug @HumeField @PeterDaszak @MarionKoopmans Sorry, but if anything Dr Tedros showed extraordinary courage in pushing back against "premature" efforts to dismiss lab origin. And rightly so given Peter Ben Embarek's revelation that the investigation was a sham.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@SteveStuWill @WashburneAlex

Copy as image

Copied to clipboard!

Holtz @Biorealism
@JonesKeto @JamieMetzl @HouseCommerce Sachs and Harrison outlined potential US evidence that a bipartisan investigation should consider. https://www.pnas.org/doi/10.1073/pnas.2202769119

Copy as image

Copied to clipboard!

Holtz @Biorealism
@LarryBoorstein @BiophysicsFL 'Leading' in a manufactured sense that many experts (often with vested interests) have said it's the leading theory. Although we have seen public views don't necessarily reflect private views on this topic and some may simply be averse to discussing it as Richard Muller found.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@TheEconomist Unless you have an anonymous survey it's misleading to say that is the leading theory. Richard A. Muller found his virology colleagues were afraid to even discuss the lab origin scenario.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@TheEconomist Nikolai Petrovsky and David Winkler noted how surprising it was humans topped the list for binding affinity from the outset. This fits with serial passage in humanized mice. https://t.co/eqjAUx9X7g
Holtz @Biorealism
: @TheEconomist Several experts outlined in the Lancet that serial passage in humanized mice would explain the remarkable binding affinity to human cells. Something the Wuhan Institute of Virology was doing prior to the pandemic. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)02019-5/fulltext

Copy as image

Copied to clipboard!

Holtz @Biorealism
@TheEconomist Nikolai Petrovsky and David Winkler noted how surprising it was humans topped the list for binding affinity from the outset. This fits with serial passage in humanized mice.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@_mustard_seeds @TheEconomist Indeed.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@linkerstein @TheEconomist Not in private.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@TheEconomist In *private* the expert view has always been that Sars-CoV-2 arose from a lab accident. There is zero evidence for zoonotic spillover.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@kelrobi11 @TheEconomist There were specific warnings in December 2017 from the likes of Marc Lipsitch, Carl T Bergstrom and @R_H_Ebright that lifting the moratorium on gain-of-function research on potential pandemic pathogens like SARS risked a pandemic that would kill millions. And here we are.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Silenthorizen @NewstalkZB He said he wanted to run last week but it was subject to the local branch. Clearly he's not far left enough for them.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Rebecca21951651 @88Otters @MarionKoopmans @Ayjchan @Rimo42 @NVMM_NL WHO 2006:new epidemic of SARS would most likely emerge from an animal reservoir or a laboratory doing research with live cultures of SARS-CoV or handling clinical specimens containing SARS-CoV. The risk of re-emergence from a laboratory source is thought to be potentially greater https://t.co/if3zRm10r4
Holtz @Biorealism
: @Rebecca21951651 @88Otters @MarionKoopmans @Ayjchan @Rimo42 @NVMM_NL Shan-Lu Liu: The Wuhan lab has many bat samples not yet worked out or results published. There are some concerns that some of their samples may not have been handled properly and leaked out of the lab...just a possibility.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Rebecca21951651 @88Otters @MarionKoopmans @Ayjchan @Rimo42 @NVMM_NL WHO 2006:new epidemic of SARS would most likely emerge from an animal reservoir or a laboratory doing research with live cultures of SARS-CoV or handling clinical specimens containing SARS-CoV. The risk of re-emergence from a laboratory source is thought to be potentially greater

Copy as image

Copied to clipboard!

Holtz @Biorealism
@firehorsemia @bgflyingcircus That is consistent with serial passage in humanized mice though. Something that was done at Wuhan Institute of Virology with the studies on Sars-related bat coronavirus. https://t.co/e7YhCE078V https://t.co/mXnU8Je7Ox
Holtz @Biorealism
: @firehorsemia @bgflyingcircus Various experts remarked on how unusual the furin site was, particularly the lack of surrounding amino acid changes. Later it turned out that the Wuhan Institute of Virology was part of a proposal to introduce furin cleavage sites into novel SARS-related bat coronaviruses.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@firehorsemia @bgflyingcircus None have a furin cleavage site let alone emerged with humans having the highest binding affinity from the outset. Nikolai Petrovsky and David Winkler noted this was particularly surprising and unlike previous zoonotic viruses. https://t.co/qTpJMaR0Am https://t.co/NDqwp1J0ST
Holtz @Biorealism
: @firehorsemia @bgflyingcircus That is consistent with serial passage in humanized mice though. Something that was done at Wuhan Institute of Virology with the studies on Sars-related bat coronavirus. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)02019-5/fulltext

Copy as image

Copied to clipboard!

Holtz @Biorealism
@firehorsemia @bgflyingcircus None have a furin cleavage site let alone emerged with humans having the highest binding affinity from the outset. Nikolai Petrovsky and David Winkler noted this was particularly surprising and unlike previous zoonotic viruses. https://www.nature.com/articles/s41598-021-92388-5

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @GooseHonks @RepMGriffith @R_H_Ebright In December 2017 the likes of Marc Lipsitch and Carl T. Bergstrom actually warned that lifting the moratorium on gain-of-function research on potential pandemic pathogens like SARS risked a pandemic that would kill millions.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @firehorsemia @bgflyingcircus The likes of Marc Lipsitch and Carl Bergstrom actually warned in December 2017 that lifting the moratorium on gain-of-function research on potential pandemic pathogens like SARS risked a pandemic that would kill millions.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@GooseHonks @RepMGriffith @R_H_Ebright Various experts have called for a proper investigation of the lab origin scenario in the Lancet and Science. Mike Farzan, Marc Eloit and others have noted the surprising binding affinity to human cells may be explained by serial passage in humanized mice. https://t.co/e7YhCE078V https://t.co/SnVwv9ipPB
Holtz @Biorealism
: @GooseHonks @RepMGriffith @R_H_Ebright Nikolai Petrovsky and David Winkler noted the animal Sars-CoV-2 jumped from should top the list for binding affinity. Instead, humans have topped the list from the outset. https://www.nature.com/articles/s41598-021-92388-5

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @GooseHonks @RepMGriffith @R_H_Ebright Various experts have called for a proper investigation of the lab origin scenario in the Lancet and Science. Mike Farzan, Marc Eloit and others have noted the surprising binding affinity to human cells may be explained by serial passage in humanized mice. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)02019-5/fulltext

Copy as image

Copied to clipboard!

Holtz @Biorealism
@bobkcus @HansMahncke @RepMGriffith There needs to be a rapid response group emailing/advising those on the subcommittee when you get experts who are as misinformed as Michael Imperiale. Not sure he looked very closely at work the Wuhan Institute of Virology was undertaking. https://t.co/0jtsCU6LO6
Holtz @Biorealism

Copy as image

Copied to clipboard!

Holtz @Biorealism
@bobkcus @HansMahncke @RepMGriffith There needs to be a rapid response group emailing/advising those on the subcommittee when you get experts who are as misinformed as Michael Imperiale. Not sure he looked very closely at work the Wuhan Institute of Virology was undertaking.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@VBruttel @MarionKoopmans @Ayjchan @Rimo42 @NVMM_NL Proximal Origin co-author Ian Lipkin on finding out some of the Wuhan Institute of Virology's work was done in BSL-2 labs: "That's screwed up...It shouldn't have happened. People should not be looking at bat viruses in BSL-2 labs. My view has changed.".

Copy as image

Copied to clipboard!

Holtz @Biorealism
@HeerRozenwater @mattwridley Philipp Markolin a marketing person at @3brain on Alina Chan, a biologist at the Broad Institute. https://t.co/31ann8CT8G
Holtz @Biorealism
: @HeerRozenwater @mattwridley @3Brain Richard A. Muller found his virology colleagues were afraid to even discuss the lab origin scenario. @EmaNymton90 was also told by her virology colleagues not to discuss it.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@HeerRozenwater @mattwridley Philipp Markolin a marketing person at @3brain on Alina Chan, a biologist at the Broad Institute.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@joodge64 @JoePompliano Why would Djokovic (or any player) make up an injury and put uncomfortable tape on your leg for no reason? The timing works out according to Dr Peter Bruckner who has worked with Liverpool & Cricket Australia. https://metajaunnews.com/djokovic-could-have-withstood-hamstring-injury-to-claim-grand-slam-doctor-says/?feed_id=22768&_unique_id=63db346415f8a

Copy as image

Copied to clipboard!

Holtz @Biorealism
@docjjk5 @JoePompliano Why would Djokovic (or any player) make up an injury and put uncomfortable tape on your leg for no reason? The timing works out according to Dr Peter Bruckner who has worked with Liverpool & Cricket Australia. https://metajaunnews.com/djokovic-could-have-withstood-hamstring-injury-to-claim-grand-slam-doctor-says/?feed_id=22768&_unique_id=63db346415f8a

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Reddog50071259 @MarkGottlieb @willthom04 @RonnyLerner Why would Djokovic (or any player) make up an injury and put uncomfortable tape on your leg for no reason? The timing works out according to Dr Peter Bruckner who has worked with Liverpool & Cricket Australia. https://metajaunnews.com/djokovic-could-have-withstood-hamstring-injury-to-claim-grand-slam-doctor-says/?feed_id=22768&_unique_id=63db346415f8a

Copy as image

Copied to clipboard!

Holtz @Biorealism
@ColinDavdButler In 'Collapse' Jared Diamond discussed how population pressure was a factor in the Rwandan massacre.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @JonesKeto @DebSeligsohn gain-of-function research on potential pandemic pathogens like SARS risked a pandemic that would kill millions. Bergstrom, Marc Lipsitch, Ebright and others said this might happen.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@humblesci @garyruskin @csmonitor @christacbryant @Slate Yes, @christacbryant given there is evidence of self-censorship on this contentious topic you would need an anonymous survey to get a true gauge of expert opinion on Covid19 origins. Richard A Muller found his virology colleagues were afraid to even discuss the lab scenario.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@atuntable @zasdak @BlockedVirology @Rebecca21951651 @R_H_Ebright @ASMicrobiology

Copy as image

Copied to clipboard!

Holtz @Biorealism
@hankhepler @PaulNuki @R_H_Ebright EcoHealth Alliance had a shared database with Wuhan Institute of Virology. https://t.co/1fMBFqlwRH https://t.co/enJv7lhMQN
Holtz @Biorealism
: @hankhepler @PaulNuki @R_H_Ebright A problem Shan-Lu Liu noted was the Wuhan Institute of Virology had many bat samples that weren't worked up or published. RaTG13 was only uploaded 2 years after it was sequenced. They weren't uploading all findings to international databases. What became of this for example?

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @hankhepler @PaulNuki @R_H_Ebright EcoHealth Alliance had a shared database with Wuhan Institute of Virology. http://web.archive.org/web/20201102074943/http://institute.wuhanvirology.org/International_Cooperation2016/International_Projects2016/

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @PaulNuki Recall there were specific warnings in December 2017 from the likes of Marc Lipsitch, Carl T Bergstrom and @R_H_Ebright that lifting the moratorium on gain-of-function research on potential pandemic pathogens like SARS risked a pandemic that would kill millions.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @khoobehi Recall that in December 2017, the likes of Marc Lipsitch and Carl Bergstrom warned that lifting the moratorium on gain-of-function research on potential pandemic pathogens like SARS risked a pandemic that would kill millions.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@TheTropaion @BiophysicsFL @ercpact @peter_g_knight @ERC_Research @R_H_Ebright @Ayjchan @gdemaneuf Here is an analysis from last year that includes raccoon dogs. I think @Daoyu15 covered this elsewhere. https://www.nature.com/articles/s41421-022-00431-0#Fig1

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @der_stuart @R_H_Ebright @mattwridley @jehrenreich @Slate @Globalbiosec So we have seen people saying the lab origin idea began with Trump or the GOP, completely ignoring that Chinese researchers Botao and Lei Xiao argued lab origin was likely on 6 February 2020 and various experts were privately saying the same in the US.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@TheTropaion @ercpact @peter_g_knight @ERC_Research @R_H_Ebright Not that I'm aware of. In terms of your second question the Nature paper linked above noted there was minimal early evidence of selection pressure to further optimize binding, in contrast to other zoonotic viruses. https://t.co/d4Drleac21
Holtz @Biorealism
: @TheTropaion @ercpact @peter_g_knight @ERC_Research @R_H_Ebright @Ayjchan and colleagues had an interesting analysis about this. https://www.biorxiv.org/content/10.1101/2020.05.01.073262v1.abstract

Copy as image

Copied to clipboard!

Holtz @Biorealism
@TheTropaion @ercpact @peter_g_knight @ERC_Research @R_H_Ebright Not that I'm aware of. In terms of your second question the Nature paper linked above noted there was minimal early evidence of selection pressure to further optimize binding, in contrast to other zoonotic viruses.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@BiophysicsFL @InWuchang @CD57227 @pathogenetics @dr_handler @Florin_Uncovers No idea what other essays are like, but the fact it features the cynical piece by Neil et al. arguing Sars-CoV-2 didn't arise from GoF research while omitting the DEFUSE proposal, doesn't bode well. @peter_g_knight @ERC_Research https://i.stuff.co.nz/national/health/coronavirus/300424689/revealed-wuhan-and-us-scientists-planned-to-create-new-coronaviruses

Copy as image

Copied to clipboard!

Holtz @Biorealism
@ercpact @peter_g_knight @ERC_Research @R_H_Ebright Mike Farzan, Marc Eloit and various experts have also noted serial passage in humanized mice may have been involved and would explain why Sars-CoV-2 emerged better adapted to human ACE2 cells than any other species. https://t.co/e7YhCE078V https://t.co/A3qm9v2PmD
Holtz @Biorealism
: @ercpact @peter_g_knight @ERC_Research @R_H_Ebright Nikolai Petrovsky and David Winkler noted the fact humans topped the list for binding affinity from the outset was particularly surprising and unlike previous zoonotic viruses. https://www.nature.com/articles/s41598-021-92388-5

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @ercpact @peter_g_knight @ERC_Research @R_H_Ebright Mike Farzan, Marc Eloit and various experts have also noted serial passage in humanized mice may have been involved and would explain why Sars-CoV-2 emerged better adapted to human ACE2 cells than any other species. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)02019-5/fulltext

Copy as image

Copied to clipboard!

Holtz @Biorealism
@octoberistired @Slate Incredible that the likes of Marc Lipsitch and Carl T Bergstrom specifically warned that lifting the moratorium on gain-of-function research on potential pandemic pathogens like SARS risked a pandemic that would kill millions. Huge vested interests against an investigation.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @Ted_Pope @Slate Recall the likes of Marc Lipsitch and Carl Bergstrom warned that lifting the moratorium on gain-of-function research on potential pandemic pathogens like SARS risked a pandemic that would kill millions.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@ancapdavid @chrisluxonmp @dbseymour I was interested to read this highly critical assessment by what sounds to be a traditional labour voter on the Standard site.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@dbseymour A traditional left wing voter on the Standard reflects on the Ardern era.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@FactualAfterDrk @iluminatibot Still meaning to read this.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@NewsroomNZ @JamesHalcrow A reflection on Ardern's legacy from a commentator on the Left. https://thestandard.org.nz/jacinda-ardern-has-announced-she-is-standing-down-as-pm/

Copy as image

Copied to clipboard!

Holtz @Biorealism
@StephKT1313 @simon_gordon_ @R_H_Ebright @DavidBahry @gdemaneuf Nikolai Petrovsky and David Winkler noted it was quite different to previous zoonotic spillovers in that humans topped the list for binding affinity from the outset. That seems consistent with serial passage in humanized mice? https://www.nature.com/articles/s41598-021-92388-5

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @desktopcarl @onzamap_nz @R_H_Ebright @DavidBahry This is another observation that at first glance seems at odds with the market scenario? Anyway, I'm putting kid's to bed before I settle down to watch the Australian Open. Thanks for your comments. https://www.nature.com/articles/s41598-021-92388-5

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @DennisSweitzer @RadCentrism @tyoiujhgffvhpo @R_H_Ebright @InnerA1000006 @DavidBahry Aside from the furin site and codon usage, another oddity that was noted by Nikolai Petrovsky and David Winkler was SARS-CoV-2 emerged with greater binding affinity to human ACE2 cells than other species. https://www.nature.com/articles/s41598-021-92388-5

Copy as image

Copied to clipboard!

Holtz @Biorealism
@RadCentrism @tyoiujhgffvhpo @R_H_Ebright @InnerA1000006 There were likely earlier cases. Seafood market origin seems inconsistent with Sars-CoV-2 having stronger binding affinity to human ACE2 cells than to other species from the outset. Something that troubled Nikolai Petrovsky and David Winkler.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@stevcho91 Indeed, it's probably what happened.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@simon_gordon_ @R_H_Ebright @StephKT1313 @DavidBahry @gdemaneuf But would they be counted as the new virus? For example, see the reports here of an unusually severe influenza and schools closing classes in November 2019. Early patient samples were destroyed too?

Copy as image

Copied to clipboard!

Holtz @Biorealism
@simon_gordon_ @R_H_Ebright @StephKT1313 @DavidBahry @gdemaneuf But would they be counted as the new virus? For example, see the reports here of an unusually severe influenza and schools closing classes in November 2019. Early patient samples were destroyed too?

Copy as image

Copied to clipboard!

Holtz @Biorealism
@simon_gordon_ @R_H_Ebright @StephKT1313 @DavidBahry @gdemaneuf The theory that Sars-CoV-2 emerged from the market in December 2019 also seems inconsistent with the observation of Nikolai Petrovsky and David Winkler that humans topped the list for binding affinity from the outset? https://t.co/qPhPPubmhH
Holtz @Biorealism
: @simon_gordon_ @R_H_Ebright @StephKT1313 @DavidBahry @gdemaneuf If they knew it was a leak what do you think they would have done differently? They couldn't really have been any less transparent in terms of efforts to investigate the origins. Why was the military brought in to run the WIV?

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @simon_gordon_ @R_H_Ebright @StephKT1313 @DavidBahry @gdemaneuf The theory that Sars-CoV-2 emerged from the market in December 2019 also seems inconsistent with the observation of Nikolai Petrovsky and David Winkler that humans topped the list for binding affinity from the outset?

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @RollingStone @karavoght The backdrop is a long running debate over the risks of gain-of-function research on potential pandemic pathogens like SARS. The likes of Carl T Bergstrom, Marc Lipsitch & @R_H_Ebright warned that lifting the moratorium in December 2017 risked a pandemic that would kill millions.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@NathanJRobinson @DavidBahry Just in terms of Vietnam some have said Star Wars was an allegory for US imperialism specifically around the Vietnam War. George Lucas discussed these themes with Avatar director James Cameron a few years ago. https://www.amc.com/blogs/george-lucas-reveals-how-star-wars-was-influenced-by-the-vietnam-war--1005548

Copy as image

Copied to clipboard!

Holtz @Biorealism
@MJnanostretch @atuntable @gtuckerkellogg The early case data was described by David Relman as "hopelessly impoverished" & @gdemaneuf @DavidBahry have noted various biases in how they were recorded. Market origin also seems inconsistent with the binding affinity to human ACE2 noted by Nikolai Petrovsky and David Winkler?

Copy as image

Copied to clipboard!

Holtz @Biorealism
@silentanb @LettersfromTim Nikolai Petrovsky and David Winkler noted it was very odd that humans top the list for binding affinity. The species it came from should be the best fit. That seems consistent with serial passage in humanized mice? https://www.nature.com/articles/s41598-021-92388-5

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Gab49932477 @LettersfromTim Worse, recall that in December 2017 the likes of Marc Lipsitch, Carl T Bergstrom and @R_H_Ebright warned that lifting the moratorium on gain-of-function research on pandemic potential pathogens like SARS risked a pandemic that would kill millions.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @LettersfromTim From the outset the fact a SARS-related bat coronavirus that infects human cells better than any other species emerged in Wuhan where a US funded institute was teaching SARS-related bat coronaviruses to infect human cells made lab origin v plausible.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@PontyIrene @nzherald A more accurate headline would be that they are returning to pre-covid levels, but even then New Zealand already had the worst housing unaffordability in the world. It's a disaster. #nzpol

Copy as image

Copied to clipboard!

Holtz @Biorealism
@LauraMiers NAC supplementation may be a good idea for this reason? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995409/

Copy as image

Copied to clipboard!

Holtz @Biorealism
@themainichi NAC supplementation might be a good idea?

Copy as image

Copied to clipboard!

Holtz @Biorealism
@primalpoly I don't know about inspriring but the Hairy Maclary and Friends Sculpture in Tauranga, NZ is definitely good for children who love the books.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@natnatnatthecat @SKGandhiMD FYI.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@ElonBachman Still looking into it, although I have a couple of bottles of capsules I ordered for Covid19 after reading it may be helpful. The guy mentioned here, Professor Russell Reiter, seems to be involved in most of the melatonin studies. He's 86 and still going strong so there's that.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@thehillbeast @SeanPlunket From 1871.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@PaulVau97741544 @TodayFM_nz

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Muller_Lab @virologyanon @EcoHealthNYC EcoHealth Alliance apparently also shared a "Viruses and Genetic Resource Database" with the Wuhan Institute of Virology. https://web.archive.org/web/20201102074943/http://institute.wuhanvirology.org/International_Cooperation2016/International_Projects2016/

Copy as image

Copied to clipboard!

Holtz @Biorealism
@BurtonComments @razibkhan Not from the US, but my understanding is the benefits of test prep are oversold and the tests do a good job predicting how people from different backgrounds will far at college. Hence UC Taskforce recommended their retention. https://spectrumnews1.com/ca/la-west/inside-the-issues/2020/02/07/task-force-says-university-of-california-should-keep-testing-requirement

Copy as image

Copied to clipboard!

Holtz @Biorealism
@R_H_Ebright @Ayjchan Or psychopaths.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Isegoria Asian students have long had the best results on these tests on average. The tests have the best predictive validity as far as I know. There was a major report on this a few years ago.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@MJnanostretch According to an anonymous doctor in @SharriMarkson's book there was a flu alert sent out to doctors warning of a severe influenza and High School classes started getting postponed in November 2019.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@R_H_Ebright @ggronvall @alisonannyoung Young is clearly right - unless there is an anonymous poll who would know what most scientists *really* think about Covid19 origins. We already know from FOIA that that given the controversial nature of the topic private views can diverge significantly from public comments. https://t.co/dcBo1Z7wpN
Holtz @Biorealism
: @R_H_Ebright @ggronvall @alisonannyoung Richard A Muller even found his virology colleagues were afraid to discuss the possibility of a lab origin for fear of blacklisting.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@R_H_Ebright @ggronvall @alisonannyoung Young is clearly right - unless there is an anonymous poll who would know what most scientists *really* think about Covid19 origins. We already know from FOIA that that given the controversial nature of the topic private views can diverge significantly from public comments.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@BiophysicsFL I'd never heard this expression, "picking up pennies in front of a steam roller." Looking it up some say it was coined by Taleb in 'Black Swan', but others note an anonymous trader was quoted using the expression in the WSJ in 1988. https://t.co/augZ5bsC2m
Holtz @Biorealism
: @BiophysicsFL Someone says they have done the math on him making that same bet everyday :-)

Copy as image

Copied to clipboard!

Holtz @Biorealism
@BiophysicsFL This was pretty much my approach when I briefly tried sports betting when I was at Uni. Sure enough eventually there was an upset. Although I was betting $100, not a million. https://t.co/l6YxyddUzO
Holtz @Biorealism
: @BiophysicsFL I'd never heard this expression, "picking up pennies in front of a steam roller." Looking it up some say it was coined by Taleb in 'Black Swan', but others note an anonymous trader was quoted using the expression in the WSJ in 1988.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@BiophysicsFL This was pretty much my approach when I briefly tried sports betting when I was at Uni. Sure enough eventually there was an upset. Although I was betting $100, not a million.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@BlissTabitha @DanRather Yes, many seem unaware that Fauci and Francis Collins are long time supporters of gain-of-function research on pandemic potential pathogens despite warnings from the likes of Marc Lipsitch and Carl Bergstrom this risked a pandemic that could kill millions. https://t.co/GuzYsPkzfy
Holtz @Biorealism
: @BlissTabitha @DanRather Here is Carl T Bergstrom's scarily prescient warning in December 2017 against lifting the moratorium on gain-of-function research on pandemic potential pathogens.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@BlissTabitha @DanRather Yes, many seem unaware that Fauci and Francis Collins are long time supporters of gain-of-function research on pandemic potential pathogens despite warnings from the likes of Marc Lipsitch and Carl Bergstrom this risked a pandemic that could kill millions.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@CD57227 @zasdak @lab_leak @Florin_Uncovers It brings @3Brain into disrepute when their marketing guy @PhilippMarkolin harasses a young female scientist at Broad Institute in this manner.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@daniel_corcos Mendelsohn says he was taught at medical school in the 1950's that breast x-rays were practically worthless. https://t.co/uKa1SpB7e8
Holtz @Biorealism
: @daniel_corcos He refers to disagreement amongst experts in interpreting the films and evidence that they cause more breast cancer than they detect. Overall, he calls x-rays "the most pervasive and dangerous diagnostic tool in the doctor's office".

Copy as image

Copied to clipboard!

Holtz @Biorealism
@daniel_corcos Mendelsohn says he was taught at medical school in the 1950's that breast x-rays were practically worthless.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@daniel_corcos Just reading 'Confessions of a Medical Heretic' which came out in 1979. Mendelsohn argues breast x-rays for women under fifty, with no symptoms, and no family history of breast cancer, are unjustifiable.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@daniel_corcos @Rebecca21951651 @sciencecohen @R_H_Ebright @alisonannyoung @Ayjchan @hholdenthorp @HansMahncke In legal terms it's something that directly proves the fact in question. So a whistleblower or document confirming a lab had Sars-CoV-2.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@JonesKeto @Bryce_Nickels Lying is more cognitively demanding than telling the truth. Ironically, when he was offering his unvarnished thoughts Bob Garry raised a great point about why Sars-CoV-2 was unlikely to have arisen naturally.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@quay_dr Amy Maxmen: 2016: Honored to sit beside such experts in cholera, Zika, HIV, and more...@PeterDaszak 2020: I've never met Daszak.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@CharlesRixey @hholdenthorp and @ScienceMagazine don't want to offend their stakeholders and colleagues in China or the NIH. Thorp has already damaged his credibility by suggesting the DEFUSE work wasn't done with nothing to back it up.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Ayjchan Sachs says he was advised by a reviewer that the research was "already done" before the DEFUSE proposal was submitted.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@abhishek_s_1 @AtticusFinch_JD @Samuel_Gregson Gregson takes a blinkered view of the potential causes of SARS-CoV-2. The likes of Jack Nunberg, Justin Kinney and Rob Townley noted the DEFUSE proposal to add furin cleavage sites into novel SrCVs could have lead to SARS-CoV-2. It was v plausible even before that leaked.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@DrPalmquist Stop gain-of-function research on pandemic potential pathogens as Nick Patterson, Jesse Bloom, Richard Ebright and others have suggested.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@MJnanostretch @Muller_Lab Before he blocked me I pointed out (more than once) to Philip Markolin that Peter Ben Embarek had acknowledged the initial WHO investigators had been unable to undertake any studies on the lab leak scenario. I think he's a sociopathic liar like Peter Daszak.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@TrishtheDish_7 @ThankUBayesGod @thackerpd @R_H_Ebright @NateSilver538 Unfortunately on the issue of Covid19 origins she has proven extremely biased propagandist. A nice breakdown of one of her recent tweets by @BiophysicsFL

Copy as image

Copied to clipboard!

Holtz @Biorealism
@ChrissieEvert @Martina Just reading this great account of your rivalry and friendship. Wishing @Martina all the best.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@ShalleePage @abhishek_s_1 @zasdak @Ray_Grant_ @superbirdman1 @onthewall_fly @DrNeilStone @R_H_Ebright Yes, but the point Petrovsky makes it you would expect it to bind more effectively to the host species. With SARS1 it took a long time to develop that binding affinity for humans. This paper also outlines some of the unusual features of SARS-CoV-2. https://t.co/xGAXvslVTn https://t.co/HMz4gfzJQT
Holtz @Biorealism
: @ShalleePage @abhishek_s_1 @zasdak @Ray_Grant_ @superbirdman1 @onthewall_fly @DrNeilStone @R_H_Ebright Petrovsky's paper. I'm heading out so will respond further later. https://www.nature.com/articles/s41598-021-92388-5

Copy as image

Copied to clipboard!

Holtz @Biorealism
@ShalleePage @abhishek_s_1 @zasdak @Ray_Grant_ @superbirdman1 @onthewall_fly @DrNeilStone @R_H_Ebright Yes, but the point Petrovsky makes it you would expect it to bind more effectively to the host species. With SARS1 it took a long time to develop that binding affinity for humans. This paper also outlines some of the unusual features of SARS-CoV-2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993900/

Copy as image

Copied to clipboard!

Holtz @Biorealism
🎯
Quoted tweet unavailable

Copy as image

Copied to clipboard!

Holtz @Biorealism
@abhishek_s_1 @ShalleePage @zasdak @Ray_Grant_ @superbirdman1 @onthewall_fly @DrNeilStone @R_H_Ebright Lab origin also explains the puzzle that Nikolai Petrovsky and David Winkler noted. Humans topped the list for binding affinity to ACE2. As Petrovsky says, you would expect the species it transmitted from to come out on top. This would fit with serial passage in humanized mice. https://t.co/szzEEeWBNO
Holtz @Biorealism
: @abhishek_s_1 @ShalleePage @zasdak @Ray_Grant_ @superbirdman1 @onthewall_fly @DrNeilStone @R_H_Ebright Something Mike Farzan suggested right from the outset.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@abhishek_s_1 @ShalleePage @zasdak @Ray_Grant_ @superbirdman1 @onthewall_fly @DrNeilStone @R_H_Ebright The Chinese Academy of Sciences was also funding research at the Wuhan Institute of Virology to study the binding affinity of bat SrCVs on different ACE2. https://t.co/K5Lv9CPv4y
Holtz @Biorealism
: @abhishek_s_1 @ShalleePage @zasdak @Ray_Grant_ @superbirdman1 @onthewall_fly @DrNeilStone @R_H_Ebright Lab origin also explains the puzzle that Nikolai Petrovsky and David Winkler noted. Humans topped the list for binding affinity to ACE2. As Petrovsky says, you would expect the species it transmitted from to come out on top. This would fit with serial passage in humanized mice.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @abhishek_s_1 @ShalleePage @zasdak @Ray_Grant_ @superbirdman1 @onthewall_fly @DrNeilStone @R_H_Ebright The Chinese Academy of Sciences was also funding research at the Wuhan Institute of Virology to study the binding affinity of bat SrCVs on different ACE2.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@JoelMCurzon Either that or it came about via gain-of-function research on SARS related bat coronaviruses undertaken at the Wuhan Institute of Virology prior to the outbreak. These observations of Farzan and Liu were made even before the DEFUSE proposal to add FCS to novel SrCV was leaked.

Copy as image

Copied to clipboard!

Holtz @Biorealism
If they are not aware of the accident or if the 'fix' does not work, the next most likely step is that the workers themselves become infected...This path has been suggested as the possible source of the ongoing COVID-19 pandemic... https://t.co/xpP7QNP6k3 https://t.co/LeZUhYDF9I
Holtz @Biorealism
: When an accident leads to problems, a possible, and possibly frequent reaction by all involved (sometimes including the personnel directly involved) is to hide it...A common solution is to blame the victim and close the case without much publicity.

Copy as image

Copied to clipboard!

Holtz @Biorealism
If they are not aware of the accident or if the 'fix' does not work, the next most likely step is that the workers themselves become infected...This path has been suggested as the possible source of the ongoing COVID-19 pandemic... https://f1000research.com/articles/11-508

Copy as image

Copied to clipboard!

Holtz @Biorealism
@JanKlimkowski @Ayjchan Nikolai Petrovsky: "Strangely humans came out at the very top of the list. That is not what we were expecting as the animal host from which the virus had been transmitted should have been at the top of the list."

Copy as image

Copied to clipboard!

Holtz @Biorealism
@tweet0042 @Ayjchan Nikolai Petrovsky: "Strangely humans came out at the very top of the list. That is not what we were expecting as the animal host from which the virus had been transmitted should have been at the top of the list."

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @DedRed18 @GrayConnolly @DavidBahry That in itself isn't definitive. It's one of several pieces of evidence that in combination are more readily explained by lab origin. The location, binding affinity, furin site as proposed in DEFUSE, codon usage, lack of other amino acid changes around the furin site etc.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@DedRed18 @GrayConnolly Epidemiologist Professor Raina MacIntyre considers lab origin more likely. Location of the outbreak & features of the virus are more readily explained by lab origin. Nikolai Petrovsky and David Winkler noted the animal host would be expected to top the list for binding affinity. https://t.co/k4OKREjRt4
Holtz @Biorealism
: @DedRed18 @GrayConnolly Instead, humans top the list. Consistent with serial passage suggested by Mike Farzan early on. This was before the DEFUSE proposal to introduce furin cleavage sites into novel SARS-related bat coronaviruses was leaked.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@DedRed18 @GrayConnolly Epidemiologist Professor Raina MacIntyre considers lab origin more likely. Location of the outbreak & features of the virus are more readily explained by lab origin. Nikolai Petrovsky and David Winkler noted the animal host would be expected to top the list for binding affinity.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@mirandadevine Dear Jenny This is terrific! We are very happy that our Gain of Function research funding pause has been lifted.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@ggronvall @elonmusk @pmarca And likely caused the current pandemic. The likes of Marc Lipsitch, Carl T Bergstrom and @R_H_Ebright warned that lifting the moratorium on gain-of-function research on pandemic potential pathogens like SARS risked a pandemic that would kill millions but were ignored.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@MarioNawfal Accidental leak of an engineered virus.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @RunnerBoy52 @ydeigin @C_Kavanagh @jasonetheridge @DavidBahry Mike Farzan found the location and features of the virus made lab origin likely even before the DEFUSE proposal to add furin cleavage sites into novel SARS-related bat coronaviruses was leaked. Nick Patterson wrote that tipped it to overwhelmingly likely.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @RunnerBoy52 @ydeigin @C_Kavanagh @jasonetheridge @DavidBahry The surprise of Nikolai Petrovsky and David Winkler at humans topping the list for binding affinity is also at odds with a market origin. As Petrovsky notes, you would expect the animal host from which the virus had been transmitted at the top of the list. https://www.nature.com/articles/s41598-021-92388-5

Copy as image

Copied to clipboard!

Holtz @Biorealism
@happy_khan Surprised you consider Sars-CoV-2 almost certainly has a zoonotic origin. As Nikolai Petrovsky & David Winkler noted it's very odd that humans topped the list for binding affinity from the outset. Given the features of the virus and location of outbreak lab origin is v plausible. https://t.co/5FJTEfq2b6
Holtz @Biorealism
: @happy_khan Even before the DEFUSE proposal to introduce furin cleavage sites into novel SrCVs lab origin was seen as likely. David Relman noted the early case data that some use to argue for market origin is "hopelessly impoverished".

Copy as image

Copied to clipboard!

Holtz @Biorealism
@happy_khan Surprised you consider Sars-CoV-2 almost certainly has a zoonotic origin. As Nikolai Petrovsky & David Winkler noted it's very odd that humans topped the list for binding affinity from the outset. Given the features of the virus and location of outbreak lab origin is v plausible.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Hurri_Rain @pathogenetics @MarioNawfal The tweet lists some of the features of the virus that are consistent with lab origin? Given the location of the outbreak that is very plausible. Indeed, it's been considered likely even before the DEFUSE proposal to introduce furin cleavage sites into novel SrCVs was leaked.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Hurri_Rain @Travisdunna @pathogenetics @MarioNawfal Not with greater binding affinity to human cells than any other species from the outset. As Nikolai Petrovsky notes, "the animal from which the virus had been transmitted should have been at the top of the list."

Copy as image

Copied to clipboard!

Holtz @Biorealism
"As a general rule for getting things done the quickest, do the things that everyone else has to do at the times everyone else isn't doing them." https://t.co/XZBR36nz6w
Holtz @Biorealism
: Mark H. McCormack: "There are two things about the way I organize myself which have an almost universal application. First, write it down...Second, organize for the next day at the end of the previous day."

Copy as image

Copied to clipboard!

Holtz @Biorealism
"I have over the years developed an almost minute-by-minute awareness of how I am spending my time." https://t.co/FchmT3HoPa
Holtz @Biorealism
: "As a general rule for getting things done the quickest, do the things that everyone else has to do at the times everyone else isn't doing them."

Copy as image

Copied to clipboard!

Holtz @Biorealism
McCormack: "I beging by viewing a week as 168 hours, and I schedule time for relaxation and rest as well as work..." https://t.co/eKzGRj7jtJ
Holtz @Biorealism
: "I have over the years developed an almost minute-by-minute awareness of how I am spending my time."

Copy as image

Copied to clipboard!

Holtz @Biorealism
In the champions mind he is never ahead...I became acutely aware of this a number of years ago when I was in Osaka, Japan with Arnold Palmer and Gary Player who were in an exhibition match...Arnold sank his putt, and Gary, shaking his head, turned to me... https://t.co/J1wvJMyaSf
Holtz @Biorealism
: McCormack: "I beging by viewing a week as 168 hours, and I schedule time for relaxation and rest as well as work..."

Copy as image

Copied to clipboard!

Holtz @Biorealism
Mark H. McCormack: The champion's true edge exists solely in the mind, and over the years I have observed three attitudinal characteristics which are common to every superstar I have ever known. https://t.co/ufcmnIlQD4
Holtz @Biorealism
: In the champions mind he is never ahead...I became acutely aware of this a number of years ago when I was in Osaka, Japan with Arnold Palmer and Gary Player who were in an exhibition match...Arnold sank his putt, and Gary, shaking his head, turned to me...

Copy as image

Copied to clipboard!

Holtz @Biorealism
Mark H. McCormack: The champion's true edge exists solely in the mind, and over the years I have observed three attitudinal characteristics which are common to every superstar I have ever known.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@crazy4rottis @thackerpd @DrJBhattacharya @WashburneAlex @carlheneghan "One of the big mistakes in our field is this mantra 'Follow the science,' as though science is not contested, as though there are not evidentiary gaps... It’s a kind of moralistic scientism..."

Copy as image

Copied to clipboard!

Holtz @Biorealism
@JefeGreenfield @mindfully_aloof @hiltzikm @DavidSacks @R_H_Ebright Garry himself raised a point for lab origin based on the similarity to RaTG13 aside from the 12nt insertion that added the furin site with no other amino acid changes in the domain. Shan-Lu Liu made a similar observation. Garry's explanation anticipates the DEFUSE proposal.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@JefeGreenfield @mindfully_aloof @hiltzikm @DavidSacks @R_H_Ebright Thanks, for some reason you didn't get copied into my subsequent comments about the funding and potential proposals that could have lead to SARS-CoV-2. I disagree that lab origin is unlikely. It was considered likely even before the leaked DEFUSE proposal that Garry omits.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@morgenstern28 @DavidSacks So millions people have been killed in the pandemic. Just as the likes of Marc Lipsitch and Carl T Bergstrom warned when the moratorium on gain-of-function research on potential pandemic pathogens like SARS was lifted in 2017.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@mindfully_aloof @hiltzikm @DavidSacks @R_H_Ebright What is unclear is what results they obtained from the DEFUSE project that the likes of Jack Nunberg, Justin Kinney and Rob Townley have noted could have lead to SARS-CoV-2. It tipped Nick Patterson over to considering lab origin was very likely. https://t.co/cqWZ7Q7kPu
Holtz @Biorealism
: @mindfully_aloof @hiltzikm @DavidSacks @R_H_Ebright That wasn't funded by DARPA or the NIAID. Another question is what results came from this study on the binding affinity of bat SrCVs on different ACE2 at the Wuhan Institute of Virology. This was funded by the Chinese Academy of Sciences.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @mindfully_aloof @hiltzikm @DavidSacks @R_H_Ebright What is unclear is what results they obtained from the DEFUSE project that the likes of Jack Nunberg, Justin Kinney and Rob Townley have noted could have lead to SARS-CoV-2. It tipped Nick Patterson over to considering lab origin was very likely.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@JefeGreenfield @mindfully_aloof @hiltzikm @DavidSacks Ultimately, it's part of a long running debate where the likes of Marc Lipsitch, Carl T Bergstrom and @R_H_Ebright warned that lifting the moratorium on gain-of-function research on pandemic potential pathogens like SARS risked a pandemic that would kill millions.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@CherylRose1111 @DavidSacks Obviously not in that case! But it's not really about him or Obama. It's a long running debate between those who pushed this research and those who warned against the risks. Unfortunately those who warned about the risks were right. And it's still happening.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@ToreyJamesHall @DavidSacks It was done while the HHS was within a confirmed Secretary.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@RoomsForRent7 @DavidSacks

Copy as image

Copied to clipboard!

Holtz @Biorealism
@JohnLBauer @DavidSacks It was lifted while the HHS didn't have a confirmed Secretary.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@CherylRose1111 @DavidSacks The moratorium was lifted after the Health and Human Services Secretary had resigned and before the replacement was confirmed. https://t.co/6GnS6JWSDl
Holtz @Biorealism
: @CherylRose1111 @DavidSacks The likes of Marc Lipsitch and Carl T. Bergstrom warned that lifting the moratorium on gain-of-function research on potential pandemic pathogens like SARS risked a pandemic that would kill millions.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@CherylRose1111 @DavidSacks The moratorium was lifted after the Health and Human Services Secretary had resigned and before the replacement was confirmed.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Ayjchan Wuhan was even used as a control for serological studies on bat coronaviruses because of its urban setting. https://pubmed.ncbi.nlm.nih.gov/29500691/

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Ayjchan @ScienceMagazine Nikolai Petrovsky: "Strangely humans came out at the very top of the list. That was not what we were expecting, as the animal host from which the virus had been transmitted should have been at the top of the list."

Copy as image

Copied to clipboard!

Holtz @Biorealism
@GrayConnolly @SharriMarkson @elonmusk In December 2017, weeks after the Health and Human Services Secretary had resigned and the agency was without a confirmed Secretary, Collins' NIH and Fauci's NIAID quietly restarted funding for what was then termed "enhanced potential pandemic pathogens."

Copy as image

Copied to clipboard!

Holtz @Biorealism
@DavidSacks @BiophysicsFL In December 2017, weeks after the Health and Human Services Secretary had resigned and the agency was without a confirmed Secretary, Collins' NIH and Fauci's NIAID quietly restarted funding for what was then termed "enhanced potential pandemic pathogens." https://www.forbes.com/sites/adamandrzejewski/2021/10/20/dr-anthony-faucis-little-known-biodefense-work--its-how-he-became-the-highest-paid-federal-employee/?sh=7317b3e66081

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Mangan150 Dr Richard Neel: “When I was studying chemical and biological weapons, I found that melatonin could counteract them all…chemical, biological, and radiological weapons as well..." https://devinenews.com/dr-richard-neel-encourages-forget-about-sleep-read-the-research-on-the-anti-inflammatory-anti-oxidant-and-immunomodulatory-side-of-high-dose-melatonin/

Copy as image

Copied to clipboard!

Holtz @Biorealism
@brownecfm @CNNnews18 Nikolai Petrovsky and David Winkler were particularly surprised that unlike previous zoonotic viruses SARS-CoV-2 emerged better adapted to human ACE2 cells than any other species. https://t.co/qTpJMaR0Am https://t.co/lBeFxHO9pe
Holtz @Biorealism
: @brownecfm @CNNnews18 The Wuhan Institute of Virology with UNC were part of a 2018 proposal to introduce furin cleavage sites into novel SARS-related bat coronaviruses. The legendary computational biologist Nick Patterson recently noted this is too much of a coincidence.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@brownecfm @CNNnews18 Not sure that's correct. From the outset lab origin has been a likely explanation given the features of the virus and coincidence of it emerging near a US funded institute that was teaching SAR-related bat coronaviruses to infect human cells. https://t.co/YhxJ2izCas
Holtz @Biorealism
: @brownecfm @CNNnews18 Nikolai Petrovsky and David Winkler were particularly surprised that unlike previous zoonotic viruses SARS-CoV-2 emerged better adapted to human ACE2 cells than any other species. https://www.nature.com/articles/s41598-021-92388-5

Copy as image

Copied to clipboard!

Holtz @Biorealism
@brownecfm @CNNnews18 Not sure that's correct. From the outset lab origin has been a likely explanation given the features of the virus and coincidence of it emerging near a US funded institute that was teaching SAR-related bat coronaviruses to infect human cells.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@elonmusk @pmarca Fauci and Francis Collins were longtime supporters of gain-of-function research. When the moratorium on this research on pandemic potential pathogens like SARS was lifted in 2017, the likes of Marc Lipsitch, Carl Bergstrom and @R_H_Ebright warned it could cause a pandemic. https://t.co/Ns8NHjW5wy
Holtz @Biorealism
: @elonmusk @pmarca @R_H_Ebright In December 2017, weeks after the Health and Human Services Secretary had resigned and the agency was without a confirmed Secretary, Collins' NIH and Fauci's NIAID quietly restarted funding for what was then termed "enhanced potential pandemic pathogens." https://www.forbes.com/sites/adamandrzejewski/2021/10/20/dr-anthony-faucis-little-known-biodefense-work--its-how-he-became-the-highest-paid-federal-employee/?sh=7317b3e66081

Copy as image

Copied to clipboard!

Holtz @Biorealism
@MsNoLaJane @elonmusk @pmarca Dear Jenny This is terrific! We are very happy to hear that our Gain of Function research funding pause has been lifted. Cheers, Peter

Copy as image

Copied to clipboard!

Holtz @Biorealism
@elonmusk @pmarca Fauci and Francis Collins were longtime supporters of gain-of-function research. When the moratorium on this research on pandemic potential pathogens like SARS was lifted in 2017, the likes of Marc Lipsitch, Carl Bergstrom and @R_H_Ebright warned it could cause a pandemic.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@elonmusk @pmarca Remember Fauci told Congress the NIAID hadn't funded gain-of-function research at the Wuhan Institute of Virology? Peter Daszak obviously saw it at gain-of-function research.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@arnie03 @Sportsfreakconz Even they haven't escaped social media critics.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@BillyBostickson Berberine is sometimes discussed as a cheaper alternative to Metformin. It might help against Covid19 too.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@boulware_dr I wonder if Berberine would have a similar effect? It's sometimes discussed as a cheaper alternative.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@capitolsheila @Bryce_Nickels It is indeed increasingly hard to avoid this conclusion.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@lukele @MarioNawfal @DrLiMengYAN1 As noted early on, they also had many bat samples not worked up or published. https://t.co/f6q3LwCtbp
Holtz @Biorealism
: @lukele @MarioNawfal @DrLiMengYAN1 It's also worth noting it wasn't just the NIAID funding research on potential bat coronavirus spillover risk at the Wuhan Institute of Virology. The Chinese Academy of Sciences was too.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @lukele @MarioNawfal @DrLiMengYAN1 As noted early on, they also had many bat samples not worked up or published.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@lukele @MarioNawfal @DrLiMengYAN1 Another puzzle is the lack of amino acid changes around the furin site. Consistent with an insert. https://t.co/CqcJ3SUSyJ
Holtz @Biorealism
: @lukele @MarioNawfal @DrLiMengYAN1 Last year the DEFUSE proposal was leaked. As legendary computational biologist Nick Patterson recently noted it's too much of a coincidence that Sars-CoV-2 would emerge in Wuhan given they were part of a proposal to engineer something that would look remarkably like Sars-CoV-2.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@lukele @MarioNawfal @DrLiMengYAN1 As Nikolai Petrovsky and David Winkler noted you wouldn't expect humans to top the list for binding affinity to the new virus. That is consistent with serial passage in humanized mice though. https://t.co/qTpJMaR0Am https://t.co/iVgKWMbwQd
Holtz @Biorealism
: @lukele @MarioNawfal @DrLiMengYAN1 Another puzzle is the lack of amino acid changes around the furin site. Consistent with an insert.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@lukele @MarioNawfal @DrLiMengYAN1 It was always a likely explanation given the location of the outbreak near a US funded Institute teaching SARS-related bat coronaviruses to infect human cells. That was even before the DEFUSE proposal was leaked. https://t.co/sGk0AllJFm
Holtz @Biorealism
: @lukele @MarioNawfal @DrLiMengYAN1 As Nikolai Petrovsky and David Winkler noted you wouldn't expect humans to top the list for binding affinity to the new virus. That is consistent with serial passage in humanized mice though. https://www.nature.com/articles/s41598-021-92388-5

Copy as image

Copied to clipboard!

Holtz @Biorealism
@lukele @MarioNawfal @DrLiMengYAN1 It was always a likely explanation given the location of the outbreak near a US funded Institute teaching SARS-related bat coronaviruses to infect human cells. That was even before the DEFUSE proposal was leaked.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@quay_dr There is also evidence of school closures from early November 2019.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@quay_dr In early November 2019...a flu alert was sent out to doctors, warning them of some sort of severe influenza... he thought something was suspicious because high school classes started shutting down in November, wherever there had been infected students.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@MarioNawfal As legendary computational biologist Nick Patterson recently noted, it's overwhelmingly likely.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@TimHaldorsson @MarioNawfal It's been jarring to discover that authors of at least two early papers dismissing lab origin privately considered it was likely.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@stevieringdings @Arngrim Pritikin took his own life after a recurrence of radiation induced leukemia that had beenin remission for 27 years. His autopsy results showed his 69 yr old arteries free of disease or restriction. Which was the purpose of his diet. https://www.latimes.com/archives/la-xpm-1985-07-04-vw-9280-story.html

Copy as image

Copied to clipboard!

Copy as image

Copied to clipboard!

View @KirkegaardEmil
Holtz @Biorealism
@NonzeroPods @kausmickey @robertwrighter It seems likely SARS-CoV-2 arose from gain-of-function research at the Wuhan Institute of Virology. It's unknown whether it resulted NIAID funded research, but Fauci's long term support for this despite warnings from Marc Lipsitch and Carl Bergstrom looks reckless in hindsight.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@ProfPCDoherty @Rebecca21951651 Yes, although the circumstances make lab origin v plausible. There was a proposal to introduce naturally occurring human cleavage sites into novel SrCVs. Nikolai Petrovsky & David Winkler note unlike other zoonotic viruses SC2 was better adapted to human ACE2 than other species.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@ProfPCDoherty Holmes omits we don't know what samples Wuhan Institute of Virology had as their virus database went offline in late 2019. The NIH recently terminated their award for refusal to share records. Shan-Lu Liu also noted many bat samples weren't worked up or published.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @KarlSinclair10 @ad_quid @agent_of_change Nikolai Petrovsky and David Winkler were particularly surprised when they found it binds more effectively to human ACE2 cells than other species.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@breakfast_dogs

Copy as image

Copied to clipboard!

Holtz @Biorealism
@RitaPanahi @elonmusk

Copy as image

Copied to clipboard!

Holtz @Biorealism
@djsuperonline @audleyharrison RaTG13 is the nearest we know WIV had but as Shan-Lu Liu noted early on they had many bat samples not worked up or results published. They took their virus database offline in September 2019 and it hasn't been shared with WHO or others.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@djsuperonline @audleyharrison RaTG13 is the nearest we know WIV had but as Shan-Lu Liu noted early on they had many bat samples not worked up or results published. They took their virus database offline in September 2019 and it hasn't been shared with WHO or others.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @djsuperonline @audleyharrison The similarity with another virus held by the Wuhan Institute of Virology aside from 12nt insertion that adds the furin site with no other amino acid changes in the domain is another thing that hasn't really been well explained as far as I know.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @djsuperonline @audleyharrison For example, SARS wasn't well adapted to human cells initially while Sars-CoV-2 was straight away. That's consistent with serial passage in humanized mice something that was being done with SrCVs prior to the pandemic. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7993900/

Copy as image

Copied to clipboard!

Holtz @Biorealism
@djsuperonline @audleyharrison Ralph Baric's 'no see 'em' method means you can't tell. That said, in this case the furin cleavage site, codon usage, lack of other amino acid changes and fact it binds to human ACE2 cells better than any other species are *suggestive*. https://t.co/tGD8jaB6Dr
Holtz @Biorealism
: @djsuperonline @audleyharrison As Nikolai Petrovsky notes here, you would expect the species it came from to top the list for binding affinity, not humans. https://www.nature.com/articles/s41598-021-92388-5

Copy as image

Copied to clipboard!

Holtz @Biorealism
@djsuperonline @audleyharrison Ralph Baric's 'no see 'em' method means you can't tell. That said, in this case the furin cleavage site, codon usage, lack of other amino acid changes and fact it binds to human ACE2 cells better than any other species are *suggestive*.

Copy as image

Copied to clipboard!

Holtz @Biorealism
This editorial is well written & makes some fair points, but I think it would carry more weight if it didn't appear to make the assumption the origin of the current pandemic was known to be zoonotic. @mimperia @ACasadevall1 @GoodrumVirusLab @SSCLabQuips https://journals.asm.org/doi/10.1128/jvi.01847-22

Copy as image

Copied to clipboard!

Holtz @Biorealism
@RobertS15742004 @ASMicrobiology @florian_krammer Until there is some recognition that funding gain-of-function research on potential pandemic pathogens like SARS was a bad idea these institutions will continue to erode public trust and build the case for external regulation as suggested by Nick Patterson.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@ASMicrobiology @SSCLabQuips This is true but supporting gain-of-function research on potential pandemic pathogens like SARS in the face of warnings from the likes of Marc Lipsitch and Carl T Bergstrom that lifting the moratorium in 2017 risked a pandemic that would kill millions looks reckless in hindsight. https://t.co/95JOoX2UdE
Holtz @Biorealism
: @ASMicrobiology @SSCLabQuips Until there is some recognition of this these institutions will continue to erode public trust and build the case for external regulation as Nick Patterson suggests is needed.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@ASMicrobiology @SSCLabQuips This is true but supporting gain-of-function research on potential pandemic pathogens like SARS in the face of warnings from the likes of Marc Lipsitch and Carl T Bergstrom that lifting the moratorium in 2017 risked a pandemic that would kill millions looks reckless in hindsight.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@BlockedVirology @scotub @WashburneAlex @bealelab @TheCrick

Copy as image

Copied to clipboard!

Holtz @Biorealism
@JamieMetzl @HouseIntel @GOPHELP Lancet Covid19 Commission Chair Jeff Sachs and Neil Harrison outlined where to look for clues about the origin of SARS-CoV-2. https://www.pnas.org/doi/10.1073/pnas.2202769119

Copy as image

Copied to clipboard!

Holtz @Biorealism
@RichardHanania Haven't read Burnham's 'The Managerial Revolution' but his 'Suicide of the West' was an interesting read. Also, his observation about widespread vulnerability to communism amongst the college educated elite in his intro to 'The Secret War for the A-Bomb' appears on the money.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@SydMartin4 @abhishek_s_1 @berkley_lynch @WashburneAlex @robertson_lab @stuartjdneil @SGriffin_Lab @ArisKatzourakis I was surprised at this survey from September. People have presumably noticed the labs have refused to share their records while it's too much of a coincidence for it to arise in a city where SARS-related bat viruses were being taught to infect human cells.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @guyverhofstadt @elonmusk Note that Fauci and Francis Collins have been long-time supporters of gain-of-function research on potential pandemic pathogens like SARS despite Marc Lipsitch and Carl T Bergstrom warning lifting the moratorium in December 2017 risked a pandemic that would kill millions.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@guyverhofstadt @elonmusk Lab origin of Covid19 has in fact been seen as the most likely scenario from the outset.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@SoLeanDion @stkirsch Dmitry Kats latest protocol fwiw.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@franciscodeasis @mattwridley YouGov-Cambridge 22 September 2022 - lab 53%. I would bet it's increased since then.

Copy as image

Copied to clipboard!

Copy as image

Copied to clipboard!

Holtz @Biorealism
@berkley_lynch @WashburneAlex @robertson_lab @stuartjdneil @SGriffin_Lab @ArisKatzourakis What do you make of the DEFUSE proposal to introduce human specific cleavage sites into novel SrCVs? The likes of @jbkinney @RobTownley6 and Jack Nunberg have suggested could have lead to SARS-CoV-2 or something very similar. It also tipped the balance for Nick Patterson. https://t.co/ZzHzCwdE5S
Holtz @Biorealism
: @berkley_lynch @WashburneAlex @robertson_lab @stuartjdneil @SGriffin_Lab @ArisKatzourakis @jbkinney @RobTownley6 That would explain the lack of other amino acid changes around the furin site, codon usage, fact it emerged with stronger binding affinity for human ACE2 cells than any other species (inconsistent with market origin in December 2019). https://www.nature.com/articles/s41598-021-92388-5

Copy as image

Copied to clipboard!

Holtz @Biorealism
@berkley_lynch @WashburneAlex @robertson_lab @stuartjdneil @SGriffin_Lab @ArisKatzourakis What do you make of the DEFUSE proposal to introduce human specific cleavage sites into novel SrCVs? The likes of @jbkinney @RobTownley6 and Jack Nunberg have suggested could have lead to SARS-CoV-2 or something very similar. It also tipped the balance for Nick Patterson.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@robertson_lab @stuartjdneil @SGriffin_Lab @ArisKatzourakis The furin cleavage site hasn't been seen in other sarbecoviruses. It was one reason Mike Farzan considered lab origin the more likely cause even before the DEFUSE proposal to introduce furin cleavage sites into novel SrCVs came to light.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@berkley_lynch @WashburneAlex @robertson_lab @stuartjdneil @SGriffin_Lab @ArisKatzourakis It's hard to say as it appears many experts are silent due to the strong incentives against supporting a lab origin. An obvious issue is funding and blaming colleagues, but Richard A Muller found his virology colleagues were afraid of blacklisting in China.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@mentju4 @JonPloug @SelectGOP @Jim_Jordan Yes, a lab with many unpublished bat samples and concerns some weren't handled properly. https://t.co/rOTfQROoPB
Holtz @Biorealism
: @mentju4 @JonPloug @SelectGOP @Jim_Jordan And of course the furin site with no other amino acid changes in the domain and the virus binds more effectively to human ACE2 cells better than any other species? That surprised Nikolai Petrovsky and David Winkler. The animal it transmitted from should top the list.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@mentju4 @JonPloug @SelectGOP @Jim_Jordan Yes, a lab with many unpublished bat samples and concerns some weren't handled properly.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@noomnus There are a lot of incentives against arguing for that scenario, from funding cuts, attacks by colleagues or fears of blacklisting as Richard A Muller found with his virology colleagues.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@JamieMetzl @natashaloder Yes, but his long term support for gain-of-function research in the face of clear warnings from the likes of Marc Lipsitch, Carl T Bergstrom and @R_H_Ebright that this risked a pandemic that would kill millions looks like a catastrophic misjudgement.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@BarbraStreisand Investigating the origins of Covid19 is the least they can do for the millions of people who died. Remember in December 2017 Marc Lipsitch and Carl Bergstrom warned lifting the moratorium on gain-of-function research on potential pandemic pathogens like SARS risked a pandemic.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@LionBlogosphere @scotub It doesn't prove anything but it does suggest the Democrats should agree to a bipartisan investigation. I would like to see an anonymous survey of virologists seeing they apparently are scared to speak out (based on Richard A Muller's experience).

Copy as image

Copied to clipboard!

Holtz @Biorealism
@btabarsimd @elonmusk @Nature He could at least show some regret for supporting gain-of-function research on potential pandemic pathogens like SARS in Wuhan. He and Francis Collins ignored warnings from the likes of Marc Lipsitch and Carl Bergstrom this risked a pandemic that would kill millions.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@sardoniccomment @OmkarChandra @elonmusk @Nature He like Francis Collins have done a lot of good things but supporting gain-of-function research on potential pandemic pathogens like SARS wasn't one of them.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@LigmaVGyna @CloudAtlas_47 @elonmusk @Nature @Cornell Supporting gain-of-function research on potential pandemic pathogens like SARS was a major mistep. The likes of Marc Lipsitch and Carl Bergstrom warned that lifting the moratorium in 2017 risked a pandemic that would kill millions.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@darkpoole @elonmusk @Nature Fauci is a long time supporter of gain-of-function research on potential pandemic pathogens like SARS. The likes of Marc Lipsitch and Carl T. Bergstrom warned that lifting the moratorium in 2017 risked a pandemic that would kill millions but they were ignored.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@SherylNYT @emilyakopp Francis Collins, when he was acting Science Advisor to the WH, would have opposed any investigation. As NIH Director he and Fauci supported gain-of-function research on potential pandemic pathogens despite warnings from the likes of Marc Lipsitch and Carl Bergstrom of a pandemic.

Copy as image

Copied to clipboard!

Holtz @Biorealism
Glad to see this story about a report by Daszak's 'Independent Taskforce' has been amended. Feedback works. https://www.abc.net.au/news/2022-10-11/covid-19-transmission-human-animal-transmission/101519434

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Globalbiosec Recently got this.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@drstip @Globalbiosec I tried Enovid (nitric oxide nasal spray) when I had Covid a few months ago. There is a small study suggesting it may help clear the virus more quickly. Melatonin is another thing that looks potentially useful. https://t.co/zGrfvJt8j9
Holtz @Biorealism
: @drstip @Globalbiosec Will see how this goes.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@coreyum @conorjsugden @OwenJones84 Yes, I think an anonymous poll would be fascinating as there are obvious disincentives for those in the field. Jonathan King mentioned this also. https://nymag.com/intelligencer/article/coronavirus-lab-escape-theory.html

Copy as image

Copied to clipboard!

Holtz @Biorealism
@drstip @Globalbiosec I tried Enovid (nitric oxide nasal spray) when I had Covid a few months ago. There is a small study suggesting it may help clear the virus more quickly. Melatonin is another thing that looks potentially useful.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@conorjsugden @coreyum @OwenJones84 Ideally virologists not working with EcoHealth Alliance or research institutions in China. Richard A Muller found his virology colleagues were afraid to even discuss the lab scenario for fear of being blacklisted.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@conorjsugden @coreyum @OwenJones84 Ideally virologists not working with EcoHealth Alliance or research institutions in China. Richard A Muller found his virology colleagues were afraid to even discuss the lab scenario for fear of being blacklisted.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@conorjsugden @coreyum @OwenJones84 Ideally virologists not working with EcoHealth Alliance or research institutions in China. Richard A Muller found his virology colleagues were afraid to even discuss the lab scenario for fear of being blacklisted.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@MMKavanagh @OwenJones84 Could also try David Relman, @CT_Bergstrom, David Fisman, @GuptaR_lab, @jbloom_lab, @Globalbiosec . French researchers Virginie Courtier-Orgogozo @Biol4Ever and Etienne Decroly @DecrolyE provided a fair minded summary recently. https://theconversation-com.translate.goog/origine-du-sars-cov-2-et-du-covid-19-le-point-sur-lenquete-en-cours-et-les-dernieres-hypotheses-190890?utm_source=twitter&utm_medium=bylinetwitterbutton&_x_tr_sl=auto&_x_tr_tl=en&_x_tr_hl=en&_x_tr_pto=wapp

Copy as image

Copied to clipboard!

Holtz @Biorealism
@OwenJones84 Well there are various incentives *against* for virologists dismiss it. Funding, increased regulation, relationships with researchers in China (as Richard A Muller found), so be wary of those strongly arguing against it given the paucity of evidence and lack of transparency.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@LiveOak512 @EndWokeness Fauci was saying people could go about their lives as per usual at the end of February 2020. He wasn't giving very good advice. He was also being privately advised it was likely the result of lab research on bat coronaviruses.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Sinikkautriain1 @FridaGhitis Engineered.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Itsjoeco @EpsilonTheory Lab origin was always the most likely explanation. https://t.co/yvROWwGRGe
Holtz @Biorealism
: @Itsjoeco @EpsilonTheory Liu: "I completely agree with you, but rumor says that furin site may be engineered. Importantly, the virus RNA sequence around the furin site (288 nt), before and after, has 6.6% differences, but with no amino acid changes at all."

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Itsjoeco @EpsilonTheory Lab origin was always the most likely explanation.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@michaelzlin Chinese researchers Botao & Lei Xiao argued lab origin was the most likely explanation in a preprint on February 6, 2020. Later that month Taiwan epidemiologist Professor Fang Chi-tai argued it was v plausible too before being forced to disavow. https://t.co/knDU7i75ay https://t.co/xuCrE1mRyL
Holtz @Biorealism
: @michaelzlin And it seems various experts privately considered lab accident was a likely cause from the outset. Jonathan A. King says there were "very intense, very subtle pressures" on them not to push on issues of laboratory biohazards. https://nymag.com/intelligencer/article/coronavirus-lab-escape-theory.html

Copy as image

Copied to clipboard!

Holtz @Biorealism
@michaelzlin Chinese researchers Botao & Lei Xiao argued lab origin was the most likely explanation in a preprint on February 6, 2020. Later that month Taiwan epidemiologist Professor Fang Chi-tai argued it was v plausible too before being forced to disavow. https://nymag.com/intelligencer/article/coronavirus-lab-escape-theory.html

Copy as image

Copied to clipboard!

Holtz @Biorealism
@MarionKoopmans The curious thing is why they didn't revert back to lab origin being v plausible after the pangolin theory collapsed and it was clear Wuhan Institute of Virology had various unpublished samples?

Copy as image

Copied to clipboard!

Holtz @Biorealism
@S_hoyle9 @1goodtern It would be good to see more research on supplements Dmitry Kats had suggested.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@KarzisTina @DFisman He said he would return.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@InvestingMerc @LDjaparidze @tony_vandongen @mbalter The DEFUSE proposal sets out they were to introduce furin cleavage sites into novel bat coronaviruses.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Mark38909618 @Kommunistkevin @VaughnMises @R_H_Ebright The idea that they could exclude WIV having the virus backbone citing a 2014(!) paper in Proximal Origin was also bizarre. Further, as Shan-Lu Liu noted, Wuhan Institute of Virology had many unpublished bat samples. https://t.co/Vy086nFBGa
Holtz @Biorealism
: @Mark38909618 @Kommunistkevin @VaughnMises @R_H_Ebright Later the leaked DEFUSE proposal showed that engineering shouldn't have been ruled out as Nick Patterson recently observed.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @Mark38909618 @Kommunistkevin @VaughnMises @R_H_Ebright The idea that they could exclude WIV having the virus backbone citing a 2014(!) paper in Proximal Origin was also bizarre. Further, as Shan-Lu Liu noted, Wuhan Institute of Virology had many unpublished bat samples.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@fayeflam @JamieMetzl I wish Robert Garry could explain the similarity with another virus held by Wuhan Institute of Virology apart from the 12nt insertion that adds the furin site with no other amino acid changes. I think he was right to find it implausible this arose naturally.

Copy as image

Copied to clipboard!

Holtz @Biorealism
Reminder that Wuhan Institute of Virology sampled from Yunnan for years and had many unpublished bat samples.
Quoted tweet unavailable

Copy as image

Copied to clipboard!

Holtz @Biorealism
@MadMaxFlapper @Naomi_D_Harvey There's a reasonable likelihood the devastation resulted from scientific hubris as the likes of Carl T Bergstrom and Marc Lipsitch warned in December 2017 when the moratorium on gain-of-function research on potential pandemic pathogens like SARS was lifted.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@jtmayes3 @Scusemepassing1 @JamesCTobias Thanks, I was citing that for the point that known backbones WIV had in 2019 isn't a strong basis to exclude lab origin in 2019, especially when they apparently had many unpublished samples. Note their concerns after looking at SC2 further. The pangolin data unconvincing but also https://t.co/mBXw3LYpvO
Holtz @Biorealism
: @jtmayes3 @Scusemepassing1 @JamesCTobias the concern about the furin site. Shan-Lu Liu particularly makes a similar observation to Bob Garry about the furin insert with no surrounding amino acid changes in the domain. Easily explained by lab origin, hard to see it happening naturally.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@jtmayes3 @Scusemepassing1 @JamesCTobias Thanks, I was citing that for the point that known backbones WIV had in 2019 isn't a strong basis to exclude lab origin in 2019, especially when they apparently had many unpublished samples. Note their concerns after looking at SC2 further. The pangolin data unconvincing but also

Copy as image

Copied to clipboard!

Holtz @Biorealism
@AntGDuarte @BiophysicsFL @MichaelWorobey Shan-Lu Liu: "Wuhan lab has many bat samples not yet worked out or results published. There are some concerns that some of their samples may not have been handled properly & leaked out of the lab...just a possibility."

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @jtmayes3 @Scusemepassing1 @JamesCTobias Another research group separately noted the pangolin sequence was unconvincing and lacked a furin site. Shan-Lu Liu made the same point Bob Garry made about the lack of other amino acid changes around the furin site in SARS-CoV-2. Still not explained.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@jtmayes3 @Scusemepassing1 @JamesCTobias It does seem they were lead astray by the pangolin claims. Which raises the question why they didn't change their minds back after it turned out to be only 92% identical, no furin cleavage site. They should have known WIV may have other unpublished backbones too. In PO they https://t.co/bujtQ7BR3r
Holtz @Biorealism
: @jtmayes3 @Scusemepassing1 @JamesCTobias cited a 2014 paper to make the point they didn't use a known backbone. Which shows how much of a stretch that argument was. If they had known of the DEFUSE proposal they would have been able to answer some of the questions they had.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@jtmayes3 @Scusemepassing1 @JamesCTobias It does seem they were lead astray by the pangolin claims. Which raises the question why they didn't change their minds back after it turned out to be only 92% identical, no furin cleavage site. They should have known WIV may have other unpublished backbones too. In PO they

Copy as image

Copied to clipboard!

Holtz @Biorealism
@LionBlogosphere Seems to be some disillusionment.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@LionBlogosphere This sounds unsurprising. https://t.co/aTX8K7nOLg
Holtz @Biorealism
: @LionBlogosphere

Copy as image

Copied to clipboard!

Holtz @Biorealism
@LionBlogosphere This sounds unsurprising.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@rogermcevilly @Rebecca21951651 @mbalter @MonaRahalkar @R_H_Ebright Some of these may apply to.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @ianfmusgrave @jaredpretender @past_is_future Ultimately, the late Philip Russell was likely correct to compare the situation to the Soviet anthrax cover up.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Rebecca21951651 @stuartjdneil @R_H_Ebright @mbalter That was always a stretch. Even Drosten and Daszak were skeptical about the relevance of the pangolins. The fact that from the outset humans were top of the list for binding affinity remains suspicious.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@sanewman1 It's good to see some comments coming in questioning Garry. I like the comparison here to tactics of a defence attorney. https://www.pnas.org/doi/10.1073/pnas.2214427119

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Engineer2The @flodebarre Sachs was told the work was already done.

Copy as image

Copied to clipboard!

Holtz @Biorealism
Poll on Covid origins in this MJA InSight article about Raina MacIntyre's new book Dark Winter. MJA Insight is a newsletter for medical professionals produced by the Medical Journal of Australia (MJA).  https://insightplus.mja.com.au/2022/42/gain-of-function-research-and-the-origins-of-omicron/

Copy as image

Copied to clipboard!

Holtz @Biorealism
@CharlesRixey @MonaRahalkar 👀

Copy as image

Copied to clipboard!

Holtz @Biorealism
@RationalEntity @stone_pe @AlexWallasch That is exactly why they had a moratorium on gain-of-function research on potential pandemic pathogens like SARS from 2014-2017. The likes of Marc Lipsitch, Carl T. Bergstrom & @R_H_Ebright warned lifting the moratorium risked a pandemic that would kill millions. https://t.co/Y7YTaZKz3Q
Holtz @Biorealism
: @RationalEntity @stone_pe @AlexWallasch @R_H_Ebright Adding the furin site to a novel SARSr-CV and passaging it in humanized mice would help explain why it was so well adapted to human ACE2 cells in contrast to SARS1 right away. This is something the CDC director Dr Redfield, a virologist himself, noted. https://www.vanityfair.com/news/2022/03/the-virus-hunting-nonprofit-at-the-center-of-the-lab-leak-controversy

Copy as image

Copied to clipboard!

Holtz @Biorealism
@RationalEntity @stone_pe @AlexWallasch That is exactly why they had a moratorium on gain-of-function research on potential pandemic pathogens like SARS from 2014-2017. The likes of Marc Lipsitch, Carl T. Bergstrom & @R_H_Ebright warned lifting the moratorium risked a pandemic that would kill millions.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@stone_pe @RationalEntity @AlexWallasch Investigators at Wuhan Institute of Virology-UNC-NUS-Eco Health Alliance stated clearly their plan to insert naturally occurring cleavage sites into novel SARS-related bat coronaviruses. p.11 of DEFUSE. https://t.co/G9I2AVqTpf
Holtz @Biorealism
: @stone_pe @RationalEntity @AlexWallasch The furin cleavage site has been a feature that various experts have wondered about as it's not seen in other sarbecoviruses so the fact the Wuhan Institute of Virology was part of a proposal to introduce them into novel SrCVs makes lab origin v plausible.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@stone_pe @RationalEntity @AlexWallasch Nikolai Petrovsky and David Winkler were surprised because unlike other zoonotic viruses SARS-CoV-2 emerged better adapted to human ACE2 cells than other species. The intermediate animal host should be at the top of the list. https://t.co/qTpJMaR0Am https://t.co/eVyaUUus4B
Holtz @Biorealism
: @stone_pe @RationalEntity @AlexWallasch Investigators at Wuhan Institute of Virology-UNC-NUS-Eco Health Alliance stated clearly their plan to insert naturally occurring cleavage sites into novel SARS-related bat coronaviruses. p.11 of DEFUSE.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@stone_pe @RationalEntity @AlexWallasch Nikolai Petrovsky and David Winkler were surprised because unlike other zoonotic viruses SARS-CoV-2 emerged better adapted to human ACE2 cells than other species. The intermediate animal host should be at the top of the list. https://www.nature.com/articles/s41598-021-92388-5

Copy as image

Copied to clipboard!

Holtz @Biorealism
@gumby4christ @jhas5 @Rossana38510044 @GigaGerard @Ayjchan And Sachs says a reviewer told him the work was already done before the proposal went in.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@ch_zimmer @LuisSchang @R_H_Ebright Yes, in this case investigators at WIV-UNC-NUS-EHA stated clearly their plan to insert naturally occurring cleavage sites into novel SARSr-CV. p.11 of DEFUSE.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@ChuckPaulen @janeqiuchina @Ayjchan @TheLancet "Jeff I was the reviewer the research was done before the proposal went in"

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @EverydayFinance @willwilkinson @realchrisrufo The issues Rufo focuses on weren't obviously unpopular (is there polling data on this?).

Copy as image

Copied to clipboard!

Holtz @Biorealism
@MarionKoopmans @WashburneAlex WIV and EcoHealth were parties involved in work manipulating and studying SrCVs in Wuhan where Sars-CoV-2 arose. You work with them. In administrative law you may be seen to have an "apparent bias" on Sars-CoV-2 origins.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@EmaNymton90 @InWuchang @pathogenetics @BiotechObserver @davideyoungmd @gdemaneuf @_everythingism @Ticklicker56 @JaEsf @MJnanostretch @dr_handler @HL3133 @R_H_Ebright @PhilippMarkolin @ydeigin @EntropyChase @kcz100 @BiophysicsFL @MonaRahalkar @ryangrim @Ayjchan @USRightToKnow @mattwridley @JamieMetzl @zeynep @emilyakopp @jbloom_lab @DavidRelman @stuartjdneil I don't place much credence on those claims. I was reading the book and recalled this discussion. Here are the relevant passages. https://t.co/okG3A7dnps
Holtz @Biorealism
: @InWuchang @pathogenetics @BiotechObserver @davideyoungmd @gdemaneuf @_everythingism @Ticklicker56 @JaEsf @MJnanostretch @dr_handler @HL3133 @R_H_Ebright @PhilippMarkolin @ydeigin @EntropyChase @kcz100 @BiophysicsFL @MonaRahalkar @ryangrim @Ayjchan @USRightToKnow @mattwridley @JamieMetzl @zeynep @emilyakopp @jbloom_lab @DavidRelman @stuartjdneil Dr Wu Xiaohua apparently also made allegations on WeChat on 3 February 2020 that WIV researchers sold animals used in experiments to wet markets. They haven't been online since. She apparently also suggested it was one of 50 in a WIV database. Her connection to WIV is unknown.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@EmaNymton90 @InWuchang @pathogenetics @BiotechObserver @davideyoungmd @gdemaneuf @_everythingism @Ticklicker56 @JaEsf @MJnanostretch @dr_handler @HL3133 @R_H_Ebright @PhilippMarkolin @ydeigin @EntropyChase @kcz100 @BiophysicsFL @MonaRahalkar @ryangrim @Ayjchan @USRightToKnow @mattwridley @JamieMetzl @zeynep @emilyakopp @jbloom_lab @DavidRelman @stuartjdneil I don't place much credence on those claims. I was reading the book and recalled this discussion. Here are the relevant passages.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@davideyoungmd @BiotechObserver @InWuchang @pathogenetics @gdemaneuf @_everythingism @Ticklicker56 @JaEsf @MJnanostretch @dr_handler @HL3133 @R_H_Ebright @PhilippMarkolin @ydeigin @EntropyChase @kcz100 @BiophysicsFL @MonaRahalkar @ryangrim @Ayjchan @USRightToKnow @mattwridley @JamieMetzl @zeynep @emilyakopp @jbloom_lab @DavidRelman @stuartjdneil It covers the work of Nikolai Petrovsky well. As he and David Winkler noted, the intermediate host would be expected to be at the top of the list for binding affinity. It also highlights the efforts to conceal the outbreak and likelihood of earlier spread. https://www.nature.com/articles/s41598-021-92388-5

Copy as image

Copied to clipboard!

Holtz @Biorealism
President Xi Jinping announced a new national biosafety law on 12 February 2020.

Copy as image

Copied to clipboard!

Holtz @Biorealism
During World War II, Royal Navy Surgeon Captain T. L. Cleave was concerned about the physical ill health of many of the sailors. From his studies he concluded that most of them suffered from one overall disease he called the “Saccharine Disease” in 1956.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@fayeflam This paper looking at possible causes of SARS-CoV-2 notes how a number of incidents go unreported. https://www.sciencedirect.com/science/article/pii/S0013935122003899#bib43

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Treb1111 @All_New_to_This @C_Kavanagh @PhilippMarkolin @WashburneAlex @EmaNymton90 Yes, part of the problem is we only know of this proposal due to a leak. The lack of transparency (eg. virus database, refusal to share electronic files and lab books with the NIH) just fuels suspicion unfortunately. There also was similar research at WIV with CAS.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Treb1111 @All_New_to_This @C_Kavanagh @PhilippMarkolin @WashburneAlex @EmaNymton90 Fair enough, although that's the case for both theories at this stage. Legendary computational biologist Nick Patterson noted the circumstantial evidence certainly makes lab origin v plausible. There are a number of pieces of evidence that do. https://t.co/eJR8YbCRBD
Holtz @Biorealism
: @Treb1111 @All_New_to_This @C_Kavanagh @PhilippMarkolin @WashburneAlex @EmaNymton90 I mean, investigators at WIV-UNC-NUS-EHA stated clearly their plan to insert naturally occurring cleavage sites into novel SARSr-CV. p.11 of DEFUSE.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Treb1111 @All_New_to_This @C_Kavanagh @PhilippMarkolin @WashburneAlex @EmaNymton90 Fair enough, although that's the case for both theories at this stage. Legendary computational biologist Nick Patterson noted the circumstantial evidence certainly makes lab origin v plausible. There are a number of pieces of evidence that do.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Treb1111 @All_New_to_This @C_Kavanagh @PhilippMarkolin @WashburneAlex @EmaNymton90 WHO has every reason to want to bury the lab origin idea. Dr Tedros, who was accused of being a puppet for China was the one who pushed back against the "premature" WHO report and called for for further investigation noting lab accidents are common. https://www.npr.org/2021/07/15/1016436749/who-chief-wuhan-lab-covid-19-origin-premature-tedros

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Treb1111 @All_New_to_This @C_Kavanagh @PhilippMarkolin @WashburneAlex @EmaNymton90 She's a virologist. In terms of political circumstances aside from the issue Muller raised you had the head of the NIH describing lab leak as a "dangerous conspiracy" which would harm international harmony. It's also prevented any real investigation.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Treb1111 @All_New_to_This @C_Kavanagh @PhilippMarkolin @WashburneAlex @EmaNymton90 She's a virologist. In terms of political circumstances aside from the issue Muller raised you had the head of the NIH describing lab leak as a "dangerous conspiracy" which would harm international harmony. It's also prevented any real investigation.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@All_New_to_This @Treb1111 @C_Kavanagh @PhilippMarkolin @WashburneAlex @EmaNymton90 Epidemiologist Professor Raina MacIntyre recently noted the strong incentives involved. https://t.co/RzVqZATqzr https://t.co/aDWo1gtyOf
Holtz @Biorealism
: @All_New_to_This @Treb1111 @C_Kavanagh @PhilippMarkolin @WashburneAlex @EmaNymton90 There's also evidence of self-censorship of lab origin arguments from FOIA information. The Proximal Origin example is well known. A similar thing occurred with a paper "No credible evidence supporting claims of the laboratory engineering of SARS-CoV-2". https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054935/

Copy as image

Copied to clipboard!

Holtz @Biorealism
@All_New_to_This @Treb1111 @C_Kavanagh @PhilippMarkolin @WashburneAlex It's something anonymous virologist @EmaNymton90 has discussed. An anonymous WHO geneticist also noted this in discussing the DEFUSE proposal. https://t.co/lJaDy1jQBE https://t.co/IRv98rGQEi
Holtz @Biorealism
: @All_New_to_This @Treb1111 @C_Kavanagh @PhilippMarkolin @WashburneAlex @EmaNymton90 Epidemiologist Professor Raina MacIntyre recently noted the strong incentives involved. https://www.abc.net.au/news/2022-10-08/australia-scraps-mandatory-covid-isolation-book-red-flags/101513372

Copy as image

Copied to clipboard!

Holtz @Biorealism
@All_New_to_This @Treb1111 @C_Kavanagh @PhilippMarkolin @WashburneAlex Self-censorship is definitely an issue given the incentives against arguing for lab origin. Richard A. Muller found his virology colleagues were afraid to even discuss a lab origin scenario. https://t.co/HiglmZjiDk
Holtz @Biorealism
: @All_New_to_This @Treb1111 @C_Kavanagh @PhilippMarkolin @WashburneAlex It's something anonymous virologist @EmaNymton90 has discussed. An anonymous WHO geneticist also noted this in discussing the DEFUSE proposal. https://i.stuff.co.nz/national/health/coronavirus/300424689/revealed-wuhan-and-us-scientists-planned-to-create-new-coronaviruses

Copy as image

Copied to clipboard!

Holtz @Biorealism
@All_New_to_This @Treb1111 @C_Kavanagh @PhilippMarkolin @WashburneAlex Self-censorship is definitely an issue given the incentives against arguing for lab origin. Richard A. Muller found his virology colleagues were afraid to even discuss a lab origin scenario.

Copy as image

Copied to clipboard!

Holtz @Biorealism
"Jeff I was the reviewer the research was done before the proposal went in"
Quoted tweet unavailable

Copy as image

Copied to clipboard!

Holtz @Biorealism
@3Brain Why is your marketing person Philipp Markolin trying to diminish and bully a female Asian scientist? Shameful.

Copy as image

Copied to clipboard!

Holtz @Biorealism
It's the gross behavior of the @3Brain marketing guy that might be more off-putting?
Quoted tweet unavailable

Copy as image

Copied to clipboard!

Holtz @Biorealism
@NeuChiP @3Brain You have some interesting colleagues at 3Brain. Pretty gross behavior towards an Asian female molecular biologist at the Broad Institute.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@DenizPhd @3Brain You have some interesting colleagues. Pretty gross behavior towards an Asian female molecular biologist at the Broad Institute.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@yvessciama @flodebarre @lemondefr Indeed. Investigators at WIV-UNC-NUS-EHA stated clearly their plan to insert naturally occurring cleavage sites into novel SARSr-CV. p.11 of DEFUSE. A proposal we only know of due to a leak. Jeff Sachs was told by a reviewer the work was already done before funding was sought.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@shallit43 @TaylorHolt979 @WashburneAlex You seem to have extreme skepticism towards a possible lab origin. I'm not sure why when the nearest relatives to SC2 are from Yunnan and Laos, areas WIV sampled. There are also several pieces of evidence that @BiophysicsFL has noted that make it v plausible.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@innominata_ @Sturzen5 @breakfast_dogs Dmitry Kats was heavily promoting flush niacin, melatonin and more recently creatine.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@harishseshadri2 @ASimonaitis @MJnanostretch In Bob Garry's case, he still hasn't provided a satisfactory answer to the question he posed early on. I think that he is now acting like an advocate to protect his funders and colleagues.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@jhas5 @andrewtanyongyi @Samuel_Gregson @PhilippMarkolin @MichaelWorobey @K_G_Andersen The lead investigator Peter Ben Embarek acknowledged the first WHO investigation of the labs was a sham. Understandably, the WHO Director-General Dr Tedros called the findings "premature."

Copy as image

Copied to clipboard!

Holtz @Biorealism
@mbalter It looks like this response was hidden too.

Copy as image

Copied to clipboard!

Holtz @Biorealism
Two of my replies that linked to preprints that criticized the theory of two independent spillovers of a species-promiscuous virus that disappears from source at same time it jumps have been hidden.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@shallit43 @WashburneAlex Possibly, but your response suggests you didn't read the thread? They privately thought it may well have but omitted the arguments that supported that theory. https://t.co/HPfruAmP3F
Holtz @Biorealism
: @shallit43 @WashburneAlex Garry separately raised a similar point about the similarity with another virus held by Wuhan Institute of Virology aside from the 12nt insertion that adds the furin site but with no other amino acid changes around the furin site. Easy to do in the lab.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@shallit43 @WashburneAlex Possibly, but your response suggests you didn't read the thread? They privately thought it may well have but omitted the arguments that supported that theory. https://t.co/HPfruAmP3F
Holtz @Biorealism
: @shallit43 @WashburneAlex Garry separately raised a similar point about the similarity with another virus held by Wuhan Institute of Virology aside from the 12nt insertion that adds the furin site but with no other amino acid changes around the furin site. Easy to do in the lab.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@shallit43 @WashburneAlex Possibly, but your response suggests you didn't read the thread? They privately thought it may well have but omitted the arguments that supported that theory.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@shallit43 @WashburneAlex The investigators at WIV-UNC-NUS-EHA stated clearly their plan to insert naturally occurring cleavage sites into novel SARSr-CV. p.11 of DEFUSE. A proposal we only know of due to a leak. https://t.co/LhsnV3NW2e
Holtz @Biorealism
: @shallit43 @WashburneAlex Or even acknowledging the likelihood the Wuhan Institute of Virology had many bat samples that weren't worked out or results published.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@shallit43 @WashburneAlex Here Holmes says their is no evidence of a precursor virus at the Wuhan Institute of Virology. This omits: 1. The NIH terminated their subaward for refusal to share records of SrCV research. 2. Virus database is offline. https://t.co/iP7OJdrPSI https://t.co/OYxsihlFmI
Holtz @Biorealism
: @shallit43 @WashburneAlex The investigators at WIV-UNC-NUS-EHA stated clearly their plan to insert naturally occurring cleavage sites into novel SARSr-CV. p.11 of DEFUSE. A proposal we only know of due to a leak.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@shallit43 @WashburneAlex For context, PO authors cite a 2014 article to "irrefutably" show Sars-CoV-2 wasn't derived from a previously used virus backbone in 2019. They conclude any lab origin isn't "plausible." This is the language of advocacy, not impartial scientific opinion? https://t.co/r61ghCniAh https://t.co/pLzzGIqmDz
Holtz @Biorealism
: @shallit43 @WashburneAlex Here Holmes says their is no evidence of a precursor virus at the Wuhan Institute of Virology. This omits: 1. The NIH terminated their subaward for refusal to share records of SrCV research. 2. Virus database is offline. https://theconversation.com/amp/the-covid-lab-leak-theory-is-dead-heres-how-we-know-the-virus-came-from-a-wuhan-market-188163

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @shallit43 @WashburneAlex For context, PO authors cite a 2014 article to "irrefutably" show Sars-CoV-2 wasn't derived from a previously used virus backbone in 2019. They conclude any lab origin isn't "plausible." This is the language of advocacy, not impartial scientific opinion? https://www.nature.com/articles/s41591-020-0820-9

Copy as image

Copied to clipboard!

Holtz @Biorealism
@shallit43 @WashburneAlex Is that how you read this? Going back to Proximal Origin and the Lancet letter a number of experts, often with undisclosed COI, have dismissed lab origin in the absence of any investigation and without even addressing the points they themselves raised privately. Eg.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @BBeanRC @JamieMetzl @SmritiMallapaty In just a few years nature recombined many coronaviruses to create a CoV in Wuhan exactly as proposed in the DEFUSE grant. A FCS, an infectious clone restriction map, in Wuhan, no animal trade outbreak trail & the WIV won't share their CoV database.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@MJnanostretch @gdemaneuf Garry acknowledges there are too many people to thank for their help. The piece does read like another propaganda effort starting with the framing of lab origin as a politically motivated theory then going on to refer to racist tropes. He still hasn't addressed his own point.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Biorealism: @gdemaneuf @MJnanostretch Notice he just repeats furin cleavage sites are common amongst betacoronaviruses without acknowledging they aren't seen amongst sarbecovirus (something Megyn Kelly called him on) or the specific DEFUSE proposal.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@DavidKucher @mem_somerville There are some odd things about this piece. Garry says furin cleavage sites aren't unusual amongst betacoronaviruses but omits that they aren't seen in any other *sarbecoviruses*. He simply dodges the specific details of the DEFUSE proposal that swayed Nick Patterson. https://t.co/IQERzMtlHj
Holtz @Biorealism
: @DavidKucher @mem_somerville Particularly, it was proposed to introduce naturally occurring human cleavage sites into novel SrCVs and study them at the Wuhan Institute of Virology. The fact that Garry seemingly can't address the steel man argument for lab origin is disappointing.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@DavidKucher @mem_somerville There are some odd things about this piece. Garry says furin cleavage sites aren't unusual amongst betacoronaviruses but omits that they aren't seen in any other *sarbecoviruses*. He simply dodges the specific details of the DEFUSE proposal that swayed Nick Patterson.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@WFrancisEsq @kevinnbass That's a possible explanation for one piece of evidence that has to be explained.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@GageKMoreno @MichaelWorobey @jepekar @DavidBahry See also. https://t.co/8MD9FVnD5w https://t.co/DWvwHnrQz7
Holtz @Biorealism
: @GageKMoreno @MichaelWorobey @jepekar @DavidBahry A two jump theory also creates oddities like this? @EmaNymton90

Copy as image

Copied to clipboard!

Holtz @Biorealism
@GageKMoreno @MichaelWorobey @jepekar Does Pekar address the recent preprints that challenge this analysis? Eg. @DavidBahry https://t.co/FcxPAgXqKo https://t.co/XoIAc5clVW
Holtz @Biorealism
: @GageKMoreno @MichaelWorobey @jepekar @DavidBahry See also. https://www.biorxiv.org/content/10.1101/2022.10.10.511625v1

Copy as image

Copied to clipboard!

Holtz @Biorealism
@GageKMoreno @MichaelWorobey @jepekar Does Pekar address the recent preprints that challenge this analysis? Eg. @DavidBahry https://zenodo.org/record/7016124#.Y23hn-CrFkw

Copy as image

Copied to clipboard!

Holtz @Biorealism
@HL3133 @JessamyBagenal Thanks, I think many are unaware WIV was sampling from not just Yunnan but various locations across SE Asia including Laos.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@JessamyBagenal This is also consistent with the 2018 DEFUSE proposal as @RobTownley6 has noted?

Copy as image

Copied to clipboard!

Holtz @Biorealism
@JamieMetzl In just a few years nature recombined many coronaviruses to create a CoV in Wuhan exactly as proposed in the DEFUSE grant. A FCS, an infectious clone restriction map, in Wuhan, no animal trade outbreak trail & the WIV deletes their CoV database...

Copy as image

Copied to clipboard!

Holtz @Biorealism
@StoicObserver_ Not sure. It does seem that similar to what Greg Clark documented with fertility rates in the UK, there historically was a positive relationship there between net fertility and social status. Something Hsu also discusses. https://infoproc.blogspot.com/2011/08/demography-and-fast-evolution.html?m=1

Copy as image

Copied to clipboard!

Holtz @Biorealism
@JulHenderson99 @kaschuta He was brutally realistic, pretty much the opposite of most Western politicians.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@cliffnuttman @kausmickey True, although union membership seems to tail off before the 80's. David Frum has also observed the middle class grew significantly when the US restricted immigration.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@RBReich Also the period of immigration restriction from 1924-1965. Something David Frum has noted.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@DegenRolf As David Friedman said, some people who claim to believe in evolution deny the implications of that belief. http://daviddfriedman.blogspot.com/2008/08/who-is-against-evolution.html?m=1

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Thom_Hartmann And as David Frum has pointed out wages for lower skilled are undercut by increased immigration levels. The middle class had grown when the US reduced labor supply.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@EconomicPolicy David Frum notes the middle class grew when the US reduced immigration.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@RBReich David Frum points out the middle class grew when the US restricted immigration.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@BT_BXL @Steve_Sailer @EHBEA1 An agenda to show East Asians have higher average IQ's than other groups? Whatever their intention Lynn & Vanhanen's estimates appear to measure cognitive ability/skills whatever the cause. https://www.econstor.eu/handle/10419/102105

Copy as image

Copied to clipboard!

Holtz @Biorealism
@Richard21234864 @NZStuff That was stupid although the refusal of the MSM to acknowledge the role of NZ adding 50,000 new residents a year to the housing crisis, compared to the 80's when it was around 15,000 is a scandal.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@RacyPedersen: @Rachell66226474 @NZStuff The role of average group differences in society as discussed by Harvard geneticist David Reich also needs to be addressed.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@TaxpayersUnion Adding 50,000 new residents per year compared to the 80's when they added around 15-20,000 is a far bigger issue along with limits on land supply. #nzpol

Copy as image

Copied to clipboard!

Holtz @Biorealism
@nz_watch @bernardchickey Adding 45,000 new residents a year compared to the 80's when they added around 15-20,000 a year might be a factor too.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@1NewsNZ @jacindaardern Adding 50,000 new residents a year compared to the 80's when NZ added around 15,000 a year might he a factor. #nzpol

Copy as image

Copied to clipboard!

Holtz @Biorealism
@KirkegaardEmil East Asia too.

Copy as image

Copied to clipboard!

Holtz @Biorealism
Kevin Mitchell: Why Males are More Lkely to be Left Handed - "male mammals are expected to show larger variability than females in all traits that are, at least to some extent, influenced by X-chromosomal alleles.”  https://t.co/hXci3EzEgc https://t.co/CJUw6Dh6xU
Holtz @Biorealism
:

Copy as image

Copied to clipboard!

Holtz @Biorealism
Kevin Mitchell: Why Males are More Lkely to be Left Handed - "male mammals are expected to show larger variability than females in all traits that are, at least to some extent, influenced by X-chromosomal alleles.”  http://www.wiringthebrain.com/2020/11/a-sinister-attractor-why-males-are-more.html?spref=tw

Copy as image

Copied to clipboard!

Holtz @Biorealism
@DrugGovoruna @BiCoastalLefty @GrudzienBarbara @RBReich Right, and the prevalence of brutal tribal warfare doesn't jibe with the peacefeful egalitarian image suggested above.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@DreamsReal6 @BiCoastalLefty @GrudzienBarbara @RBReich Yes, I was just saying brutal tribal warfare was prevalent.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@BiCoastalLefty @GrudzienBarbara @RBReich Not sure that jibes with the prevalence of brutal tribal warfare, sometimes featuring scalping and cannibalism, driven in significant part over access to women and land. https://t.co/og3EQMm5rr
Holtz @Biorealism
: @BiCoastalLefty @GrudzienBarbara @RBReich

Copy as image

Copied to clipboard!

Holtz @Biorealism
@BiCoastalLefty @GrudzienBarbara @RBReich Not sure that jibes with the prevalence of brutal tribal warfare, sometimes featuring scalping and cannibalism, driven in significant part over access to women and land.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@EverydayFinance Pelosi on 24 February was encouraging people to come to Chinatown. Fauci was still telling people to continue their normal activities even later in Feb. Major failure at the top aside from Trump's clownishness.

Copy as image

Copied to clipboard!

Holtz @Biorealism
@The_Nor @trabucco_gary @carlquintanilla Nancy Pelosi on 24 February. Fauci was telling people to continue their normal activities. Total failure from the top. https://www.nbcbayarea.com/news/local/nancy-pelosi-visits-san-franciscos-chinatown/2240247/

Copy as image

Copied to clipboard!

Holtz @Biorealism
@SharonMcAuley7 @nzherald No, NZ takes about a 1000 refugees per year which is a tiny fraction of residential approvals. Since the early 90's NZ dramatically increased the annual number of residential approvals which places huge pressure on available housing. https://croakingcassandra.com/2015/06/23/immigration-policy-106-per-cent-of-net-new-housing-demand/amp/

Copy as image

Copied to clipboard!

Filter

Use the Copy image icon, and object detection annotation toggles if present, to grab toxic content. Some of these guesses will be wrong- computer vision is hard!
wolfsangel 80%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)




Classifier 20221028131014
dial 98%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)











Classifier 20221028131014
gadsden snake 97%
celtic cross 55%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)













Classifier 20221028131014
celtic cross 53%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)











Classifier 20221028131014
art_other 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)






Classifier 20221028131014
etc 93%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)













Classifier 20221028131014
map 90%
gigachad 80%
gigachad 77%
gigachad 68%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)


















Classifier 20221028131014
gigachad 74%
gigachad 67%
gigachad 60%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)
















Classifier 20221028131014
tldr 81%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)









Classifier 20221028131014
militarized 97%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)



Classifier 20221028131014
etc 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)




Classifier 20221028131014
bar graph 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)






Classifier 20221028131014
bar graph 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)


Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)


Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
bar graph 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)


Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)






Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)





















Classifier 20221028131014
art_other 69%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)


Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)





Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)





Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)







Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)



Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)


Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)










Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)



Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)








Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)


Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)









Classifier 20221028131014
tldr 79%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)





Classifier 20221028131014
art_other 85%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)




Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)




Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)


Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
logos_flags_graphics 67%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)


Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)




Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)


Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)




Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)



Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)




Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
logos_flags_graphics 77%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)



Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)





Classifier 20221028131014
tldr 97%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)



Classifier 20221028131014

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)


Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)





Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)











Classifier 20221028131014
mspaint style 96%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)



Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)



Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%
afa flags 60%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)


Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)









Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)






Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)









Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)









Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)




Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 95%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)





Classifier 20221028131014
tldr 33%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)








Classifier 20221028131014
art_other 67%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)


Classifier 20221028131014
bar graph 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)






Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)







Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)












Classifier 20221028131014
art_other 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)


Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)







Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)



Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)






Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)


Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)




Classifier 20221028131014
tldr 42%
art_other 31%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)




Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)




Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
bar graph 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)


Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)


Classifier 20221028131014
tldr 64%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)






Classifier 20221028131014
map 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)






Classifier 20221028131014
tldr 98%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)



Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)


Classifier 20221028131014
tldr 87%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)



Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)



Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)









Classifier 20221028131014
hitler 29%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)




Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)









Classifier 20221028131014
tldr 33%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)




Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)


Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 97%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)







Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)





Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)



Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)





Classifier 20221028131014
tldr 47%
art_other 29%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)




Classifier 20221028131014
bar graph 54%
map 40%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)











Classifier 20221028131014
map 82%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)












Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)


Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)





Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)












Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)


Classifier 20221028131014
bar graph 98%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)






Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)








Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)


Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)



Classifier 20221028131014
etc 90%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)




Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)






Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)





Classifier 20221028131014
critters 71%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)



Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)






Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)







Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)





Classifier 20221028131014
tldr 98%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)




Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)




Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)






Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)






Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)



Classifier 20221028131014
tldr 94%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)















Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)





Classifier 20221028131014
logos_flags_graphics 54%
toons other 26%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)






Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)








Classifier 20221028131014
tldr 85%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)





Classifier 20221028131014
map 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)






Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)


Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)






Classifier 20221028131014
bar graph 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)





Classifier 20221028131014
map 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)





Classifier 20221028131014
tldr 84%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)





Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)








Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)





Classifier 20221028131014
bar graph 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)








Classifier 20221028131014
tldr 70%
freemasonry 29%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)




Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)



Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)






Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)




Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)


Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)


Classifier 20221028131014
tldr 66%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)


Classifier 20221028131014
tldr 97%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)






Classifier 20221028131014
tldr 97%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)









Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)








Classifier 20221028131014
bar graph 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)


Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)




Classifier 20221028131014
tldr 96%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 90%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)




Classifier 20221028131014
tldr 59%
map 40%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)






Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)




Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)









Classifier 20221028131014
star of david 64%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)




Classifier 20221028131014
bar graph 97%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)








Classifier 20221028131014
bar graph 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)



Classifier 20221028131014
bar graph 59%
tldr 39%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)




















Classifier 20221028131014
logos_flags_graphics 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)






Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)








Classifier 20221028131014
tldr 94%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)








Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)
















Classifier 20221028131014
map 98%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)
















Classifier 20221028131014
tldr 95%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)





Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)


Classifier 20221028131014
tldr 71%
bar graph 27%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)







Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
map 94%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)


Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)






Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)








Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)







Classifier 20221028131014
map 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)





Classifier 20221028131014
tldr 81%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)


Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)








Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)


Classifier 20221028131014
map 100%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)

Classifier 20221028131014
tldr 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)






Classifier 20221028131014
bar graph 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)



Classifier 20221028131014
bar graph 99%

Copy image with current annotations Copied to clipboard!

Object Detector 20221101171408 (everything)




Classifier 20221028131014
tldr 100%